Radio(chemo)therapy in Elderly Patients with Esophageal Cancer: A Feasible Treatment with an Outcome Consistent with Younger Patients

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State: Public
Version: Final published version
Serval ID
serval:BIB_E882851FCEC2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Radio(chemo)therapy in Elderly Patients with Esophageal Cancer: A Feasible Treatment with an Outcome Consistent with Younger Patients
Journal
Frontiers In Oncology
Author(s)
Rochigneux P., Resbeut M., Rousseau F., Bories E., Raoul J.L., Poizat F., Moureau-Zabotto L.
ISSN
2234-943X (Electronic)
ISSN-L
2234-943X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
4
Pages
100
Language
english
Notes
Publication types: Oncology ; research-article Identifiant PubMed Central: PMC4026749
Abstract
BACKGROUND: Although the prevalence of esophageal cancer increases in elderly patients, its clinical history and outcome after treatment remain poorly described.
METHODS: Between January 2001 and December 2011, 58 patients (pts) older than 75 years received 3D-conformal radiotherapy (mean dose 51 Gy) in two French cancer centers. 47/58 (82%) patients received concomitant chemotherapy (with CDDP and/or FU regimens) and 8 patients underwent surgery after primary radiochemotherapy (RCT).
RESULTS: Median age was 77.9 years and the performance status (PS) was 0 or 1 in 89%. Tumors were mainly adenocarcinoma of lower esophagus or gastroesophageal junction (n = 51, 89%), T3T4 (n = 54, 95%), and N1 (n = 44, 77%). The mean follow-up was 21.9 months. In the overall population, the median progression-free survival was 9.6 months and median overall survival (OS) was 14.5 months. Using univariate analysis, OS was significantly associated with age (p = 0.048), PS (p < 0.001), and surgery (p = 0.035). 35 (60.3%) and 18 patients (31%) experienced grade 1-2 or 3-4 toxicity, respectively (CTCAE v4.0).
CONCLUSION: Radiochemotherapy in elderly patients is a feasible treatment and its outcome is close to younger patient's outcome published in the literature. Surgical resection, after comprehensive geriatric assessment, should be recommended as the standard treatment for adenocarcinoma of lower esophagus or gastroesophageal junction in elderly patients with good PS and low co-morbidity profile, as it is in younger patients.
Keywords
esophageal neoplasm, elderly patients, radiotherapy, chemoradiotherapy, esophagectomy
Pubmed
Open Access
Yes
Create date
11/07/2016 10:04
Last modification date
20/08/2019 16:11
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