The efficacy and toxicity of EGFR in the settings of radiotherapy: focus on published clinical trials.

Details

Serval ID
serval:BIB_E877F7604DFF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The efficacy and toxicity of EGFR in the settings of radiotherapy: focus on published clinical trials.
Journal
European Journal of Cancer
Author(s)
Magné N., Chargari C., Castadot P., Ghalibafian M., Soria J.C., Haie-Meder C., Bourhis J., Deutsch E.
ISSN
1879-0852 (Electronic)
ISSN-L
0959-8049
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
44
Number
15
Pages
2133-2143
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Basic research in solid malignant tumours has led to a wealth of knowledge about this disease process and about novel ways to more effectively target our therapies. Laboratory research continues to identify novel therapeutic targets and moreover, clinical research is identifying effective new treatment regimens. Many preclinical studies in this area have targeted the epidermal growth factor receptor (EGFR) signalling pathway to increase radiosensitivity. The in vitro rationale for targeting EGFR and concurrent ionising radiation is well established, but to date, rare clinical data could provide proof-of-principle. Here we report all the different published clinical trials focusing on efficacy and toxicity in order to clarify and to summarise the present state-of-the-art of this particularly promising combination in solid tumour management.
Keywords
Antibodies, Monoclonal/therapeutic use, Antibodies, Monoclonal, Humanized, Antineoplastic Agents/therapeutic use, Clinical Trials as Topic, Combined Modality Therapy, Humans, Neoplasms/drug therapy, Neoplasms/radiotherapy, Protein Kinase Inhibitors/therapeutic use, Protein-Tyrosine Kinases/antagonists & inhibitors, Quinazolines/therapeutic use, Receptor, Epidermal Growth Factor/antagonists & inhibitors, Treatment Outcome
Pubmed
Web of science
Create date
01/12/2014 17:25
Last modification date
20/08/2019 16:11
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