Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases

Details

Serval ID
serval:BIB_E848347E6AAF
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases
Journal
Nature Reviews. Immunology
Author(s)
Pantaleo  G., Harari  A.
ISSN
1474-1733 (Print)
Publication state
Published
Issued date
05/2006
Volume
6
Number
5
Pages
417-23
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: May
Abstract
At present, we only have indirect knowledge of the protective role of antigen-specific T cells in human viral infections, and it has been difficult to show a direct correlation between quantitative and qualitative measures of T-cell immunity and virus-associated diseases. However, as described in this Opinion article, recent advances in the characterization of T-cell functions and in the development of standardized T-cell assays have led to the identification of distinct functional signatures of T-cell responses that correlate with levels of viral replication and disease activity.
Keywords
Animals Epitopes, T-Lymphocyte/immunology Humans T-Lymphocyte Subsets/*immunology/metabolism/*virology Virus Diseases/*immunology/*prevention & control Viruses/*immunology
Pubmed
Web of science
Create date
25/01/2008 15:00
Last modification date
20/08/2019 16:11
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