Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi-institutional cohort.

Details

Serval ID
serval:BIB_E829BCBFE1C2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi-institutional cohort.
Journal
Head & neck
Author(s)
Elicin O., Broglie M.A., Fankhauser N., Stoeckli S.J., Pasche P., Reinhard A., Bongiovanni M., Huber G.F., Morand G.B., Soltermann A., Arnold A., Dettmer M.S., Arnoux A., Stauffer E., Espeli V., Martucci F., Aebersold D.M., Giger R.
ISSN
1097-0347 (Electronic)
ISSN-L
1043-3074
Publication state
Published
Issued date
05/2019
Peer-reviewed
Oui
Volume
41
Number
5
Pages
1395-1402
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Between the publication of the Union of International Cancer Control staging system (UICC) 7th and 8th editions, other staging algorithms for oropharyngeal squamous cell carcinoma (OPSCC) were proposed from Radiation Therapy Oncology Group (RTOG), MD Anderson Cancer Center (MDACC), and Yale University.
With C-statistics, the above-mentioned five staging algorithms were compared for overall and relapse-free survival endpoints in a multi-institutional cohort of OPSCC cases (n = 338) treated with primary surgery.
Pathological UICC 8th ed yielded the highest C-indexes in the entire cohort and in the HPV- subset, whereas MDACC was superior for HPV+ OPSCC. RTOG was the simplest and holistic algorithm with a noninferior discriminatory power.
UICC 8th ed, MDACC, and RTOG offer moderate and comparable efficacy for staging in this OPSCC patient cohort undergoing surgical treatment. Notable discrepancy between clinical and pathological UICC 8th ed algorithms poses potential concerns in diagnosis, treatment, research, and data management.
Keywords
cancer staging, head and neck cancer, human papillomavirus, oropharynx cancer, surgery
Pubmed
Web of science
Create date
11/01/2019 9:34
Last modification date
20/08/2019 17:11
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