Effect of thyroid replacement therapy on the frequency of benign atrial and ventricular arrhythmias

Details

Serval ID
serval:BIB_E7F4DA9C3B32
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of thyroid replacement therapy on the frequency of benign atrial and ventricular arrhythmias
Journal
Journal of the American College of Cardiology
Author(s)
Polikar  R., Feld  G. K., Dittrich  H. C., Smith  J., Nicod  P.
ISSN
0735-1097 (Print)
Publication state
Published
Issued date
10/1989
Volume
14
Number
4
Pages
999-1002
Notes
Journal Article --- Old month value: Oct
Abstract
Whether thyroid replacement therapy can trigger cardiac arrhythmias in patients with hypothyroidism is not known. In this prospective study, 24 h ambulatory electrocardiographic (ECG) monitoring was used to assess the frequency of atrial and ventricular premature beats in 25 patients with hypothyroidism (5 men and 20 women, aged 56 +/- 3 years) before and 3.5 +/- 0.5 months (mean +/- SEM) after thyroid replacement therapy. Plasma thyroid-stimulating hormone was 73.6 +/- 12.3 and 3.1 +/- 0.6 microU/ml and free thyroxine index was 2.4 +/- 0.4 and 9.8 +/- 0.9 micrograms/100 ml at baseline and after thyroid replacement therapy, respectively. The frequency of ventricular premature beats was not affected by thyroid replacement therapy (from 273 +/- 221 at baseline to 352 +/- 235 beats/24 h after therapy), even in patients with frequent baseline arrhythmias. In contrast, the frequency of atrial premature beats was slightly increased after thyroid replacement therapy (from 47 +/- 17 to 279 +/- 197 beats/24 h), largely as a result of changes seen in three patients. No patient developed new onset of sustained ventricular or supraventricular arrhythmias. Average, basal and maximal heart rates during ECG monitoring increased significantly after thyroid replacement therapy (average 72 +/- 2 to 80 +/- 2; basal 64 +/- 2 to 70 +/- 2; maximal 114 +/- 3 to 130 +/- 3 beats/min, respectively, p less than 0.001). In conclusion, thyroid replacement therapy is safe in patients with common benign cardiac arrhythmias, and does not trigger an increase in arrhythmia frequency except in rare patients with baseline atrial premature beats. It is, however, associated with an increase in basal, average and maximal heart rates.
Keywords
Adult Aged Cardiac Complexes, Premature/*chemically induced/diagnosis Electrocardiography, Ambulatory Female Humans Hypothyroidism/*drug therapy Male Middle Aged Prospective Studies Thyroxine/adverse effects/*therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:00
Last modification date
20/08/2019 16:10
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