Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals.

Details

Serval ID
serval:BIB_E7E78FB0F2FC
Type
Article: article from journal or magazin.
Collection
Publications
Title
Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals.
Journal
European Journal of Clinical Pharmacology
Author(s)
Gallagher P., Lang P.O., Cherubini A., Topinková E., Cruz-Jentoft A., Montero Errasquín B., Mádlová P., Gasperini B., Baeyens H., Baeyens J.P., Michel J.P., O'Mahony D.
ISSN
1432-1041 (Electronic)
ISSN-L
0031-6970
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
67
Number
11
Pages
1175-1188
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
PURPOSE: Potentially inappropriate prescribing is common in older people presenting to hospital with acute illness in Ireland. The aim of this study was to determine if this phenomenon is unique to Ireland or whether it is a more widespread problem in hospitals across Europe.
METHODS: Prospective data were collected from 900 consecutive older patients admitted to six university teaching hospitals (150 patients per centre) in Geneva (Switzerland), Madrid (Spain), Oostende (Belgium), Perugia (Italy), Prague (Czech Republic) and Cork (Ireland). Age, gender, comorbidity, cognitive status, prescription medicines taken before admission and baseline haematological, biochemical and electrocardiographic data were recorded. STOPP and Beers' criteria were applied to detect potentially inappropriate medicines (PIMs). START criteria were applied to detect potentially inappropriate prescribing omissions (PPOs).
RESULTS: The overall PIM prevalence rate was 51.3% using STOPP criteria, varying from 34.7% in Prague to 77.3% in Geneva, and 30.4% using Beer's criteria, varying from 22.7% in Prague to 43.3% in Geneva. Using START criteria, the overall PPO prevalence rate was 59.4%, ranging from 51.3% in Cork to 72.7% in Perugia. Polypharmacy predicted the presence of PIMs using STOPP criteria [with >10 medications: odds ratio (OR)  7.22, 95% confidence interval (CI) 4.30-12.12, p < 0.001] and Beers' criteria (with >10 medications: OR 4.87, 95% CI 3.00-7.90, p < 0.001). Increasing co-morbidity (Charlson Index ≥2) and age ≥85 years significantly predicted PPOs.
CONCLUSION: Potentially inappropriate drug prescribing and the omission of beneficial drugs are highly prevalent in acutely ill hospitalized older people in six European centres.
Keywords
Acute Disease/epidemiology, Aged, Aged, 80 and over, Drug Utilization Review/statistics & numerical data, Drug Utilization Review/trends, Europe, Female, Health Services for the Aged/standards, Health Services for the Aged/statistics & numerical data, Hospitals, University/standards, Hospitals, University/statistics & numerical data, Humans, Inappropriate Prescribing/statistics & numerical data, Inappropriate Prescribing/trends, Male, Prescription Drugs/administration & dosage, Prescription Drugs/adverse effects, Prevalence, Prospective Studies, Risk Factors
Pubmed
Web of science
Create date
15/04/2015 8:23
Last modification date
20/08/2019 16:10
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