Synaptic pruning by microglia is necessary for normal brain development.

Details

Serval ID
serval:BIB_E7E681250B8A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Synaptic pruning by microglia is necessary for normal brain development.
Journal
Science
Author(s)
Paolicelli R.C., Bolasco G., Pagani F., Maggi L., Scianni M., Panzanelli P., Giustetto M., Ferreira T.A., Guiducci E., Dumas L., Ragozzino D., Gross C.T.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Publication state
Published
Issued date
09/09/2011
Peer-reviewed
Oui
Volume
333
Number
6048
Pages
1456-1458
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Microglia are highly motile phagocytic cells that infiltrate and take up residence in the developing brain, where they are thought to provide a surveillance and scavenging function. However, although microglia have been shown to engulf and clear damaged cellular debris after brain insult, it remains less clear what role microglia play in the uninjured brain. Here, we show that microglia actively engulf synaptic material and play a major role in synaptic pruning during postnatal development in mice. These findings link microglia surveillance to synaptic maturation and suggest that deficits in microglia function may contribute to synaptic abnormalities seen in some neurodevelopmental disorders.
Keywords
Animals, Brain/growth & development, Brain/physiology, CX3C Chemokine Receptor 1, Chemokine CX3CL1/metabolism, Dendritic Spines/physiology, Dendritic Spines/ultrastructure, Disks Large Homolog 4 Protein, Excitatory Postsynaptic Potentials, Guanylate Kinases/analysis, Hippocampus/growth & development, Hippocampus/physiology, Long-Term Synaptic Depression, Membrane Proteins/analysis, Mice, Mice, Knockout, Microglia/physiology, Miniature Postsynaptic Potentials, Neuronal Plasticity, Patch-Clamp Techniques, Pyramidal Cells/physiology, Receptors, Chemokine/genetics, Receptors, Chemokine/metabolism, Receptors, Cytokine/genetics, Receptors, Cytokine/metabolism, Receptors, HIV/genetics, Receptors, HIV/metabolism, Signal Transduction, Synapses/physiology, Synaptosomal-Associated Protein 25/analysis
Pubmed
Web of science
Create date
18/12/2018 10:34
Last modification date
20/08/2019 16:10
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