Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner

Details

Serval ID
serval:BIB_E7DC91BCB340
Type
Article: article from journal or magazin.
Collection
Publications
Title
Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner
Journal
Concepts in Magnetic Resonance Part B-Magnetic Resonance Engineering
Author(s)
Comment A., van den Brandt B., Uffmann K., Kurdzesau F., Jannin S., Konter J.A., Hautle P., Wenckebach W.T.H., Gruetter R., van der Klink J.J.
ISSN
1552-5031
Publication state
Published
Issued date
2007
Volume
31B
Number
4
Pages
255-269
Language
english
Abstract
For most of the last forty years, the techniques of Dynamic Nuclear Polarization (DNP) have been confined to particle-physics laboratories building polarized targets, but recently it has been shown that samples similar to a solid target can be transformed into room temperature liquid solutions while retaining a high nuclear polarization. This method of "hyperpolarization" is of interest in NMR/MRI/MRS. We describe a 3.35 T DNP/9.4 T MRI installation based on a continuous-flow cryostat, using a standard wide-bore low-field NMR magnet as prepolarizer magnet and a widely available radical as polarizing agent. The interfacing to a rodent scanner requires that the infusion of the polarized solution in the animal be remotely controlled, because of limited access inside the magnet bore. Physiological constraints on the infusion rate can be a serious source of polarization loss, and the discussion of efficiency is therefore limited to that of the prepolarizer itself, i.e., the spin temperatures obtained in the solid state. To put our results in context, we summarize data obtained in targets with different types of radicals, and provide a short review of the DNP mechanisms needed in their discussion. (C) 2007 Wiley Periodicals, Inc.
Keywords
dynamic nuclear polarization, hyperpolarization, enhanced c-13 nmr, dynamic nuclear-polarization, nmr, chemistry, radicals, probe, c-13
Web of science
Create date
29/04/2013 9:41
Last modification date
20/08/2019 16:10
Usage data