Hépatite autoimmune : mise au point 2021 [Autoimmune hepatitis: 2021 update]

Details

Serval ID
serval:BIB_E7CF6654AD62
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Hépatite autoimmune : mise au point 2021 [Autoimmune hepatitis: 2021 update]
Journal
Revue medicale suisse
Author(s)
Stamm G.M., Sempoux C., Fraga M., Comte D., Aubert V., Moradpour D., Vionnet J. (co-last), Moschouri E.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
01/09/2021
Peer-reviewed
Oui
Volume
17
Number
748
Pages
1457-1463
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Autoimmune hepatitis is a rare disease which can present as acute or chronic forms and can be difficult to diagnose due to its variable clinical presentation. The disease arises in genetically susceptible individuals and several triggers have been identified. The diagnosis is based on the presence of autoantibodies, elevated transaminases and serum immunoglobulin G levels as well as a compatible histology. First-line immunosuppressive treatment strategies lead to clinical remission in most patients. In case of non-response, second-line therapies can be used and in case of hepatocellular insufficiency, liver transplantation remains an excellent option.
Keywords
Autoantibodies, Hepatitis, Autoimmune/diagnosis, Hepatitis, Autoimmune/drug therapy, Hepatitis, Autoimmune/epidemiology, Humans, Immunosuppressive Agents/therapeutic use, Liver Transplantation
Pubmed
Create date
04/10/2021 14:06
Last modification date
17/11/2021 6:39
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