Prevalence of insulin resistance syndrome in southwestern France and its relationship with inflammatory and hemostatic markers

Details

Serval ID
serval:BIB_E7C002408C41
Type
Article: article from journal or magazin.
Collection
Publications
Title
Prevalence of insulin resistance syndrome in southwestern France and its relationship with inflammatory and hemostatic markers
Journal
Diabetes Care
Author(s)
Marques-Vidal P., Mazoyer E., Bongard V., Gourdy P., Ruidavets J.B., Drouet L., Ferrières J.
ISSN
0149-5992 (Print)
ISSN-L
0149-5992
Publication state
Published
Issued date
2002
Volume
25
Number
8
Pages
1371-1377
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
OBJECTIVE: To assess the prevalence and relationships of insulin resistance syndrome (IRS) with inflammatory and hemostatic markers in a representative sample of the population of Southwestern France aged 35-64 years.
RESEARCH DESIGN AND METHODS: In this cross-sectional study, data were collected from 597 men and 556 women and were assessed regarding BMI, blood pressure, total and HDL cholesterol levels, triglyceride level, glucose level, plasma insulin level, white blood cell count, fibrinogen level, factor VII level, von Willebrand factor, C-reactive protein level, soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule-1, and soluble CD(14). Insulin resistance was defined by homeostasis model assessment > or =3.8.
RESULTS: Prevalence of IRS was higher in men than in women (23 vs. 12%, respectively; P < 0.001) and increased with age in both sexes (9, 24, and 34% for age groups 35-44, 45-54, and 55-64 years, respectively, for men and 4, 10, and 21% for women). After adjusting for age, alcohol consumption, tobacco smoking, and also for menopause in women, subjects (men and women) with IRS had significantly higher white blood cell count, factor VII levels, coagulating factor VII levels, and C-reactive protein levels than the other subjects. In men, further increases in soluble intercellular adhesion molecule and soluble vascular cell adhesion molecule-1 were noted, whereas in women, the differences were borderline significant. Conversely, no differences were found in fibrinogen, von Willebrand factor, and soluble CD(14) in both sexes.
CONCLUSIONS: IRS is relatively common in residents of Southwestern France and is related to a deleterious increase in hemostatic and inflammatory parameters.
Keywords
Cardiovascular Diseases/diagnosis, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/immunology, France/epidemiology, Metabolic Syndrome X/diagnosis, Metabolic Syndrome X/epidemiology, Metabolic Syndrome X/immunology
Pubmed
Web of science
Open Access
Yes
Create date
01/12/2016 15:01
Last modification date
20/08/2019 16:10
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