Influence of non-penetrating glaucoma surgery on aqueous outflow facility in isolated porcine eyes

Details

Serval ID
serval:BIB_E7BAA41BFAF5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Influence of non-penetrating glaucoma surgery on aqueous outflow facility in isolated porcine eyes
Journal
British Journal of Ophthalmology
Author(s)
Shaarawy  T., Wu  R., Mermoud  A., Flammer  J., Haefliger  I. O.
ISSN
0007-1161 (Print)
Publication state
Published
Issued date
07/2004
Volume
88
Number
7
Pages
950-2
Notes
Journal Article --- Old month value: Jul
Abstract
PURPOSE: To investigate, in vitro, the influence of non-penetrating glaucoma surgery (NPGS) and the influence of tightly suturing the superficial scleral flap on the aqueous outflow facility of isolated porcine eyes.Materials and methods: The anterior chambers of 12 enucleated porcine cadaver eyes were cannulated and perfused. NPGS was performed by the same surgeon. The overall ocular aqueous outflow facilities were assessed before and after the surgical interventions of NPGS, as well as after scleral flap closure. RESULTS: The mean (SD) aqueous outflow facility, which was 0.164 (0.014) microl/min/mm Hg before surgery, increased significantly after NPGS to 1.584 (0.217) microl/min/mm Hg, p<0.001. When the superficial flap was closed, the aqueous outflow facility significantly decreased (0.754 (0.107) microl/min/mm Hg, p<0.001) but remained significantly higher than preoperatively (p<0.01). After suturing the superficial flap, the overall resistance increased to 1.625 (0.210) microl/min/mm Hg. The difference in the resistance to outflow before and after flap closure was 0.848 (0.169) microl/min/mm Hg. CONCLUSION: After NPGS suturing the scleral flap can modulate aqueous outflow resistance. The experimental set up described might provide an efficient model for the technical training of glaucoma surgeries.
Keywords
Animals Anterior Chamber/surgery Aqueous Humor/*physiology Eye Enucleation/methods Glaucoma/physiopathology/*surgery Sclera/surgery Surgical Flaps Sutures Swine
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 12:49
Last modification date
20/08/2019 16:10
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