Multi-cohort study identifies social determinants of systemic inflammation over the life course.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_E7A2ECA848A6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Multi-cohort study identifies social determinants of systemic inflammation over the life course.
Journal
Nature communications
Author(s)
Berger E., Castagné R., Chadeau-Hyam M., Bochud M., d'Errico A., Gandini M., Karimi M., Kivimäki M., Krogh V., Marmot M., Panico S., Preisig M., Ricceri F., Sacerdote C., Steptoe A., Stringhini S., Tumino R., Vineis P., Delpierre C., Kelly-Irving M.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
15/02/2019
Peer-reviewed
Oui
Volume
10
Number
1
Pages
773
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relationship between socioeconomic position (SEP) across the life course and inflammation (as measured by CRP levels) in up to 23,008 participants from six European cohort studies from three countries conducted between 1958 and 2013. We find a consistent inverse association between SEP and CRP across cohorts, where participants with a less advantaged SEP have higher levels of inflammation. Educational attainment is most strongly related to inflammation, after adjusting for health behaviours, body mass index and later-in-life SEP. These findings suggest socioeconomic disadvantage in young adulthood is independently associated with later life inflammation calling for further studies of the pathways operating through educational processes.
Keywords
Body Mass Index, C-Reactive Protein/metabolism, Female, Health Behavior, Humans, Inflammation/immunology, Inflammation/metabolism, Male, Regression Analysis, Risk Factors, Socioeconomic Factors
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2019 10:10
Last modification date
20/08/2019 17:10
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