Effects of membrane lipid and fluidity modifications on HIV-1 infectibility of primate lymphocytes in vitro.

Details

Serval ID
serval:BIB_E78378DF9B6C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effects of membrane lipid and fluidity modifications on HIV-1 infectibility of primate lymphocytes in vitro.
Journal
Bioscience Reports
Author(s)
Zimmer J.P., Lehr H.A., Hübner C., Lindner S.G., Ramsperger R., Claussen M., Kohlschütter A., Schmitz H.
ISSN
0144-8463 (Print)
ISSN-L
0144-8463
Publication state
Published
Issued date
1990
Volume
10
Number
3
Pages
263-270
Language
english
Abstract
Although most non-human primates, except the chimpanzee and the gibbon in vivo are not infectible by HIV-1, lymphocytes of several of these species can be infected by HIV-1 in vitro. In order to investigate whether the in vitro infectibility of primate lymphocytes might be attributed to plasma membrane adaptation processes or to serum factors, we compared HIV-1 infectibility of cultivated peripheral blood lymphocytes of macaques and of baboons on day one and on day ten of cultivation. These data were correlated to plasma membrane lipid composition and membrane fluidity. We found a correlation between increased HIV-1 in vitro infectibility and changes in plasma membrane lipid composition resulting in decreased membrane fluidity of cultured primate lymphocytes.
Keywords
Animals, HIV-1/physiology, Lymphocytes/microbiology, Lymphocytes/physiology, Macaca radiata, Membrane Fluidity/physiology, Membrane Fusion/physiology, Membrane Lipids/metabolism, Papio, Receptors, HIV/physiology, Virus Replication/physiology
Pubmed
Create date
25/11/2011 18:38
Last modification date
20/08/2019 16:10
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