Papillary Thyroid Carcinoma with Desmoid-Type Fibromatosis: Review of Published Cases.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_E774E4C20ED0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Papillary Thyroid Carcinoma with Desmoid-Type Fibromatosis: Review of Published Cases.
Journal
Cancers
Author(s)
Roukain A., La Rosa S., Bongiovanni M., Nicod Lalonde M., Cristina V., Montemurro M., Cochet S., Luquain A., Kopp P.A., Sykiotis G.P.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
06/09/2021
Peer-reviewed
Oui
Volume
13
Number
17
Pages
4482
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Desmoid-type fibromatosis (DTF) is a very rare variant of papillary thyroid carcinoma (PTC). It is essentially a dual tumor with a component of classical PTC with malignant epithelial proliferation (BRAF-mutated) and another component of mesenchymal proliferation (CTNNB1-mutated). We conducted a literature review on PTC-DTF. In total, 31 articles were identified, that together reported on 54 patients. The mean age was 47 years, with a 2.2:1 female predominance. No ultrasound features were found to be helpful in differentiating PTC-DTF from other PTC variants. Of the 43 cases that reported histological details, 60% had locally infiltrative disease (T3b or T4). Around 48% had cervical lymph node metastases, but none had distant metastases. While PTC-DTF may be locally more aggressive than classic PTC, its overall behavior is similar and can include extrathyroidal extension and lymph node metastases, which may contain a stromal component and show extranodal invasion. The mainstay of treatment for PTC-DTF is surgery, and the DTF component is not expected to be sensitive to radioactive iodine. External radiotherapy, non-steroidal anti-inflammatory drugs, tyrosine kinase inhibitors and chemotherapy have also been used in selected cases. Due to the rarity of these tumors and the lack of specific treatment guidelines, management should be discussed in a multidisciplinary team.
Keywords
BRAF, CTNNB1, desmoid-type fibromatosis, nodular fasciitis-like stroma, papillary thyroid cancer
Pubmed
Web of science
Open Access
Yes
Create date
13/09/2021 6:59
Last modification date
22/09/2021 5:38
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