Hepatectomy in patients with inherited blood coagulation disorders can be safely performed with adequate coagulation factor replacement.

Details

Serval ID
serval:BIB_E76E02A25678
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hepatectomy in patients with inherited blood coagulation disorders can be safely performed with adequate coagulation factor replacement.
Journal
Haemophilia
Author(s)
Kobayashi K., Kokudo T., Yamaguchi T., Shirata C., Uldry E., Akamatsu N., Arita J., Kaneko J., Yasumoto A., Demartines N., Hasegawa K., Halkic N.
ISSN
1365-2516 (Electronic)
ISSN-L
1351-8216
Publication state
Published
Issued date
05/2019
Peer-reviewed
Oui
Volume
25
Number
3
Pages
463-467
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Haemophilia and von Willebrand disease (VWD) are common inherited bleeding disorders. Although patients with haemophilia or VWD have a high risk of hepatitis virus infection and hepatocellular carcinoma (HCC), little is known about the safety of liver resection in these patients.
From 2006 to 2016, there were seven hepatectomies with haemophilia A and three hepatectomies with VWD for malignant liver tumours at tertiary care hospitals in Japan and Switzerland. To evaluate the safety of hepatectomy in the blood coagulation disorder group (BD group), short-term outcomes in these patients were compared with 20 hepatectomies (non-BD group) for HCC, matched to a 2:1, operative procedure, period and background liver.
Ten liver resections were performed in patients with haemophilia or VWD with administration of recombinant FVIII or VWF concentrate. Comparison of the BD vs non-BD group revealed no significant differences in the operative time (327 vs 407 minutes, P = 0.359), estimated blood loss (730 vs 820 mL, P = 0.748), red blood cell transfusion rate (10.0% vs 5.0%, P = 0.605), major complication rate (Clavien-Dindo grade III or IV) (10.0% vs 5.0%, P = 0.605) or mortality rate (0% vs 0%, P > 0.999). Additionally, the length of the postoperative hospital stay was similar between the two groups (13 vs 14 days, P = 0.296).
Liver resection for treatment of HCC in patients with haemophilia or VWD can be safely performed through an appropriate perioperative administration protocol of coagulation factors.
Keywords
Aged, Blood Coagulation Factors/metabolism, Female, Hemophilia A/metabolism, Hemophilia A/surgery, Hepatectomy/adverse effects, Humans, Male, Middle Aged, Safety, Treatment Outcome, von Willebrand Diseases/metabolism, von Willebrand Diseases/surgery, hemophilia, hepatectomy, inherited blood coagulation disorders, von Willebrand disease
Pubmed
Web of science
Create date
18/06/2019 17:39
Last modification date
16/11/2019 7:16
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