Focalized external radiotherapy for resected solitary brain metastasis: does the dogma stand?

Details

Serval ID
serval:BIB_E76CE997C47F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Focalized external radiotherapy for resected solitary brain metastasis: does the dogma stand?
Journal
Radiotherapy and Oncology
Author(s)
Coucke  P. A., Zouhair  A., Ozsahin  M., De Tribolet  N., Mirimanoff  R. O.
ISSN
0167-8140 (Print)
Publication state
Published
Issued date
04/1998
Volume
47
Number
1
Pages
99-101
Notes
Clinical Trial
Clinical Trial, Phase I
Clinical Trial, Phase II
Comparative Study
Journal Article --- Old month value: Apr
Abstract
PURPOSE: To investigate whether whole brain irradiation might be replaced by focalized irradiation after resection of a single brain metastasis in patients where extracranial tumor control is deemed to be obtained. PATIENTS AND METHODS: Twelve patients were introduced in a phase I/II prospective study of conformal postoperative external irradiation after resection of a solitary brain metastasis. The radiation treatment consisted of 50.4 Gy (1.8 Gy per fraction, five fractions per week). The planning target volume consisted of the tumor bed and a 2 cm safety margin. All treatments were optimized with head immobilization, dedicated tomodensitometry and computer assisted three-dimensional treatment planning. RESULTS: The median survival was 7.2 months (range 2.4-50.4 months). Eleven of the 12 patients died. Eight of the 12 patients presented intracranial recurrence and seven died as a consequence of intracranial tumor progression. CONCLUSIONS: Focalized external irradiation cannot serve as a reasonable alternative to whole brain radiotherapy (WBRT) even for patients with apparently one single resected brain metastasis. The dogma of 'one metastasis = multiple metastases' seems to be confirmed.
Keywords
Adult Aged Brain Neoplasms/mortality/*radiotherapy/secondary/surgery Disease Progression Female Follow-Up Studies Humans Male Middle Aged Neoplasm Recurrence, Local/mortality Prospective Studies Radiotherapy Dosage Survival Rate Treatment Outcome
Pubmed
Web of science
Create date
24/01/2008 17:20
Last modification date
20/08/2019 16:10
Usage data