Effects of physiotherapy and home-based training in parkinsonian syndromes: protocol for a randomised controlled trial (MobilityAPP).

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_E7502754E0B4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of physiotherapy and home-based training in parkinsonian syndromes: protocol for a randomised controlled trial (MobilityAPP).
Journal
BMJ open
Author(s)
Raccagni C., Sidoroff V., Paraschiv-Ionescu A., Roth N., Schönherr G., Eskofier B., Gassner H., Kluge F., Teatini F., Seppi K., Goebel G., Benninger D.H., Aminian K., Klucken J., Wenning G.
ISSN
2044-6055 (Electronic)
ISSN-L
2044-6055
Publication state
Published
Issued date
01/05/2024
Peer-reviewed
Oui
Volume
14
Number
5
Pages
e081317
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Clinical Trial Protocol
Publication Status: epublish
Abstract
Gait and mobility impairment are pivotal signs of parkinsonism, and they are particularly severe in atypical parkinsonian disorders including multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). A pilot study demonstrated a significant improvement of gait in patients with MSA of parkinsonian type (MSA-P) after physiotherapy and matching home-based exercise, as reflected by sensor-based gait parameters. In this study, we aim to investigate whether a gait-focused physiotherapy (GPT) and matching home-based exercise lead to a greater improvement of gait performance compared with a standard physiotherapy/home-based exercise programme (standard physiotherapy, SPT).
This protocol was deployed to evaluate the effects of a GPT versus an active control undergoing SPT and matching home-based exercise with regard to laboratory gait parameters, physical activity measures and clinical scales in patients with Parkinson's disease (PD), MSA-P and PSP. The primary outcomes of the trial are sensor-based laboratory gait parameters, while the secondary outcome measures comprise real-world derived parameters, clinical rating scales and patient questionnaires. We aim to enrol 48 patients per disease group into this double-blind, randomised-controlled trial. The study starts with a 1 week wearable sensor-based monitoring of physical activity. After randomisation, patients undergo a 2 week daily inpatient physiotherapy, followed by 5 week matching unsupervised home-based training. A 1 week physical activity monitoring is repeated during the last week of intervention.
This study, registered as 'Mobility in Atypical Parkinsonism: a Trial of Physiotherapy (Mobility_APP)' at clinicaltrials.gov (NCT04608604), received ethics approval by local committees of the involved centres. The patient's recruitment takes place at the Movement Disorders Units of Innsbruck (Austria), Erlangen (Germany), Lausanne (Switzerland), Luxembourg (Luxembourg) and Bolzano (Italy). The data resulting from this project will be submitted to peer-reviewed journals, presented at international congresses and made publicly available at the end of the trial.
NCT04608604.
Keywords
Humans, Physical Therapy Modalities, Exercise Therapy/methods, Parkinsonian Disorders/rehabilitation, Parkinsonian Disorders/therapy, Double-Blind Method, Randomized Controlled Trials as Topic, Gait, Parkinson Disease/rehabilitation, Parkinson Disease/therapy, Multiple System Atrophy/rehabilitation, Multiple System Atrophy/therapy, Supranuclear Palsy, Progressive/therapy, Supranuclear Palsy, Progressive/rehabilitation, Home Care Services, Aged, Male, Female, Gait Disorders, Neurologic/rehabilitation, Gait Disorders, Neurologic/etiology, Gait Analysis, Multiple System Atrophy, Parkinson-s disease, Rehabilitation medicine
Pubmed
Open Access
Yes
Create date
03/05/2024 15:12
Last modification date
04/05/2024 7:19
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