Systematic analysis of bypass suppression of essential genes.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_E6E9FA206068
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Systematic analysis of bypass suppression of essential genes.
Journal
Molecular systems biology
Author(s)
van Leeuwen J., Pons C., Tan G., Wang J.Z., Hou J., Weile J., Gebbia M., Liang W., Shuteriqi E., Li Z., Lopes M., Ušaj M., Dos Santos Lopes A., van Lieshout N., Myers C.L., Roth F.P., Aloy P., Andrews B.J., Boone C.
ISSN
1744-4292 (Electronic)
ISSN-L
1744-4292
Publication state
Published
Issued date
09/2020
Peer-reviewed
Oui
Volume
16
Number
9
Pages
e9828
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Essential genes tend to be highly conserved across eukaryotes, but, in some cases, their critical roles can be bypassed through genetic rewiring. From a systematic analysis of 728 different essential yeast genes, we discovered that 124 (17%) were dispensable essential genes. Through whole-genome sequencing and detailed genetic analysis, we investigated the genetic interactions and genome alterations underlying bypass suppression. Dispensable essential genes often had paralogs, were enriched for genes encoding membrane-associated proteins, and were depleted for members of protein complexes. Functionally related genes frequently drove the bypass suppression interactions. These gene properties were predictive of essential gene dispensability and of specific suppressors among hundreds of genes on aneuploid chromosomes. Our findings identify yeast's core essential gene set and reveal that the properties of dispensable essential genes are conserved from yeast to human cells, correlating with human genes that display cell line-specific essentiality in the Cancer Dependency Map (DepMap) project.
Keywords
compensatory evolution, gene essentiality, genetic interactions, genetic networks, genetic suppression
Pubmed
Web of science
Open Access
Yes
Create date
20/09/2020 16:46
Last modification date
28/11/2020 7:11
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