High constant incidence rates of second cutaneous melanomas

Details

Serval ID
serval:BIB_E6E8D191C03B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
High constant incidence rates of second cutaneous melanomas
Journal
International Journal of Cancer
Author(s)
Levi Fabio, Randimbison Lalao, Te Van Cong, La Vecchia Carlo
ISSN
0020-7136
Publication state
Published
Issued date
2005
Volume
117
Number
5
Pages
877-879
Notes
SAPHIRID:47429
Abstract
The incidence of most epithelial cancers rises with a power of age. However, second breast cancers have a high constant incidence independent of age. The skin is one of the few other sites allowing examination of age incidence curves of second neoplasms of the same organ. We considered the risk of second primary cutaneous malignant melanoma (CMM) in a population-based series of 3,439 first CMM registered and followed-up between 1974 and 2003 in the Swiss Cantons of Vaud and Neuchatel (about 786,000 inhabitants). A total of 43 cases of second CMM were observed vs. 9.3 expected, corresponding to a standardized incidence ratio (SIR) of 4.6. The SIR was 8.5 under age 50, 5.7 at age 50-59 and 3.5 at age 60 or over. At 20 years, the cumulative risk of second CMM was 5%. Age-specific incidence rates of second primary CMM did not vary across age groups 30-39 through 80+, ranging between 1 and 2.5 per 1,000 person-years. Thus, the risk of CMM is substantially increased in subjects diagnosed with a CMM, and the relative risk is greater at younger age and declines with advancing age. The high constant incidence curve of second CMM is compatible with the occurrence of a single mutational event in a population of susceptible individuals. [Ed.]
Keywords
Melanoma , Skin Neoplasms
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2008 9:29
Last modification date
20/08/2019 16:10
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