Head and neck tumors angiogenesis imaging with <sup>68</sup>Ga-NODAGA-RGD in comparison to <sup>18</sup>F-FDG PET/CT: a pilot study.

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Serval ID
serval:BIB_E6DE9EF09E34
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Head and neck tumors angiogenesis imaging with <sup>68</sup>Ga-NODAGA-RGD in comparison to <sup>18</sup>F-FDG PET/CT: a pilot study.
Journal
EJNMMI research
Author(s)
Durante S., Dunet V., Gorostidi F., Mitsakis P., Schaefer N., Delage J., Prior J.O.
ISSN
2191-219X (Print)
ISSN-L
2191-219X
Publication state
Published
Issued date
07/05/2020
Peer-reviewed
Oui
Volume
10
Number
1
Pages
47
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Angiogenesis plays an important role in head and neck squamous cell carcinoma (HNSCC) progression. This pilot study was designed to compare the distribution of <sup>68</sup> Ga-NODAGA-RGD PET/CT for imaging α <sub>v</sub> β <sub>3</sub> integrins involved in tumor angiogenesis to <sup>18</sup> F-FDG PET/CT in patients with HNSCC.
Ten patients (aged 58.4 ± 8.3 years [range, 44-73 years], 6 males, 4 females) with a total of 11 HNSCC were prospectively enrolled. Activity mapping and standard uptake values (SUV) from both <sup>68</sup> Ga-NODAGA-RGD and <sup>18</sup> F-FDG PET/CT scans were recorded for primary tumor and compared with the Wilcoxon signed-rank test. The relation between the SUV of both tracers was assessed using the Spearman correlation.
All HNSCC tumors were visible with both tracers. Quantitative analysis showed higher <sup>18</sup> F-FDG SUV <sub>max</sub> in comparison to <sup>68</sup> Ga-NODAGA-RGD (14.0 ± 6.1 versus 3.9 ± 1.1 g/mL, p = 0.0017) and SUV <sub>mean</sub> (8.2 ± 3.1 versus 2.0 ± 0.8 g/mL, p = 0.0017). Both <sup>18</sup> F-FDG and <sup>68</sup> Ga-NODAGA-RGD uptakes were neither correlated with grade, HPV status nor p16 protein expression (p ≥ 0.17).
All HNSCC tumors were detected with both tracers with higher uptake with <sup>18</sup> F-FDG, however. <sup>68</sup> Ga-NODAGA-RGD has a different spatial distribution than <sup>18</sup> F-FDG bringing different tumor information.
NCT, NCT02666547. Registered 12.8.2012.
Keywords
18F-FDG, 68Ga-NODAGA-RGD, Angiogenesis, Head and neck cancer, PET
Pubmed
Web of science
Open Access
Yes
Create date
15/06/2020 15:12
Last modification date
15/01/2021 7:12
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