Association between prescription drugs and all-cause mortality risk in the UK population.

Details

Serval ID
serval:BIB_E6DBF1EBA2F4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association between prescription drugs and all-cause mortality risk in the UK population.
Journal
Aging cell
Author(s)
Morin J., Rolland Y., Bischoff-Ferrari H.A., Ocampo A., Perez K.
ISSN
1474-9726 (Electronic)
ISSN-L
1474-9718
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Although most drugs currently approved are meant to treat specific diseases or symptoms, it has been hypothesized that some might bear a beneficial effect on lifespan in healthy older individuals, outside of their specific disease indication. Such drugs include, among others, metformin, SGLT2 inhibitors and rapamycin. Since 2006, the UK biobank has recorded prescription medication and mortality data for over 500'000 participants, aged between 40 and 70 years old. In this work, we examined the impact of the top 406 prescribed medications on overall mortality rates within the general population of the UK. As expected, most drugs were linked to a shorter lifespan, likely due to the life-limiting nature of the diseases they are prescribed to treat. Importantly, a few drugs were associated with increased lifespans, including notably Sildenafil, Atorvastatin, Naproxen and Estradiol. These retrospective results warrant further investigation in randomized controlled trials.
Keywords
aging, all‐cause mortality, biobank, lifespan, medications, mortality risk, prescription drugs, repurposing
Pubmed
Web of science
Open Access
Yes
Create date
11/10/2024 12:24
Last modification date
29/10/2024 7:21
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