From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions.

Details

Serval ID
serval:BIB_E6DBD6E9E696
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions.
Journal
FEBS Letters
Author(s)
Caputo T., Gilardi F., Desvergne B.
ISSN
1873-3468 (Electronic)
ISSN-L
0014-5793
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
591
Number
19
Pages
3061-3088
Language
english
Abstract
The close association of obesity with an increased risk of metabolic diseases, such as insulin resistance, type 2 diabetes, and nonalcoholic fatty liver disease, is now well established. In this review, we aim first to describe the inflammatory process activated in response to overnutrition, especially in the liver and the adipose tissue. We then discuss the systemic effects of low-grade inflammation on the onset of insulin resistance. Particular attention is given to a series of very recent reports that identify not only processes but also molecules (lipids and metabolites) that interfere with the normal insulin signaling. Finally, special notes concerning the roles of peroxisome proliferator-activated receptors in the various processes will be made.

Keywords
Adipose Tissue/pathology, Animals, Chronic Disease, Humans, Inflammation/pathology, Insulin Resistance, Liver/pathology, Models, Biological, Overnutrition/pathology, PPARs, insulin resistance, liver-adipose tissue cross-talk, metaflammation, visceral white adipose tissue
Pubmed
Web of science
Create date
26/07/2017 15:41
Last modification date
20/08/2019 17:09
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