Tumeurs stromales digestives: rôle de la tomodensitometrie avant et apres traitement [Gastrointestinal stromal tumors: role of computed tomography before and after treatment].

Details

Serval ID
serval:BIB_E6C0A5662A03
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Tumeurs stromales digestives: rôle de la tomodensitometrie avant et apres traitement [Gastrointestinal stromal tumors: role of computed tomography before and after treatment].
Journal
Gastroentérologie Clinique et Biologique
Author(s)
Bensimhon D., Soyer P., Brouland J.P., Boudiaf M., Fargeaudou Y., Rymer R.
ISSN
0399-8320 (Print)
ISSN-L
0399-8320
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
32
Number
1 Pt. 1
Pages
91-97
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review Publication Status: ppublish
Abstract
Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumors of the gastrointestinal tract. They are generally located in the stomach or the small bowel and the potential for becoming malignant varies. Due to their expression of c-kit protein, a positive diagnosis as well as a specific targeted treatment by molecular biology (imatinib) are available. Computed tomography is the best imaging method for diagnosis, staging and follow-up of GIST. They appear as a well-defined exophytic mass with heterogeneous enhancement after intravenous injection of iodinated contrast material. They may contain areas of necrosis and/or haemorrhage and enlarged lymph nodes are exceedingly rare. Most common metastatic sites are the liver and mesentery. Large tumour size and liver or mesenteric metastases are computed tomography criteria for a high malignant potential. After treatment, decrease in tumour size, number and density of lesions and the disappearance of enhancing nodules suggest a positive response to imatinib therapy, whereas a new enhancing nodule within a mass is the usual pattern of recurrence. Positron emission tomography may be useful in specific cases when clinical data are inconsistent with computed tomography criteria.
Keywords
Antineoplastic Agents/therapeutic use, Benzamides, Contrast Media, Follow-Up Studies, Gastrointestinal Stromal Tumors/radiography, Gastrointestinal Stromal Tumors/secondary, Humans, Neoplasm Recurrence, Local/radiography, Neoplasm Staging, Piperazines/therapeutic use, Prognosis, Pyrimidines/therapeutic use, Tomography, X-Ray Computed/methods, Treatment Outcome
Pubmed
Web of science
Create date
13/10/2015 9:56
Last modification date
20/08/2019 16:09
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