Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors.

Details

Serval ID
serval:BIB_E69B62B0570C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors.
Journal
Frontiers in neural circuits
Author(s)
Lefevre A., Benusiglio D., Tang Y., Krabichler Q., Charlet A., Grinevich V.
ISSN
1662-5110 (Electronic)
ISSN-L
1662-5110
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
15
Pages
688234
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Oxytocin (OT) is a neuropeptide produced by hypothalamic neurons and is known to modulate social behavior among other functions. Several experiments have shown that OT modulates neuronal activity in many brain areas, including sensory cortices. OT neurons thus project axons to various cortical and subcortical structures and activate neuronal subpopulations to increase the signal-to-noise ratio, and in turn, increases the saliency of social stimuli. Less is known about the origin of inputs to OT neurons, but recent studies show that cells projecting to OT neurons are often located in regions where the OT receptor (OTR) is expressed. Thus, we propose the existence of reciprocal connectivity between OT neurons and extrahypothalamic OTR neurons to tune OT neuron activity depending on the behavioral context. Furthermore, the latest studies have shown that OTR-expressing neurons located in social brain regions also project to other social brain regions containing OTR-expressing neurons. We hypothesize that OTR-expressing neurons across the brain constitute a common network coordinated by OT.
Keywords
Feedback, Neurons, Oxytocin, Receptors, Oxytocin, Social Behavior, anatomy, loops, oxytocin, oxytocin receptor (OTR), social brain
Pubmed
Web of science
Open Access
Yes
Create date
09/07/2021 7:46
Last modification date
02/12/2023 7:15
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