Rapid evolution of female-biased genes among four species of Anopheles malaria mosquitoes.

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State: Serval
Version: author
Serval ID
serval:BIB_E69B5D18B373
Type
Article: article from journal or magazin.
Collection
Publications
Title
Rapid evolution of female-biased genes among four species of Anopheles malaria mosquitoes.
Journal
Genome Research
Author(s)
Papa F., Windbichler N., Waterhouse R.M., Cagnetti A., D'Amato R., Persampieri T., Lawniczak MKN, Nolan T., Papathanos P.A.
ISSN
1549-5469 (Electronic)
ISSN-L
1088-9051
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
27
Number
9
Pages
1536-1548
Language
english
Abstract
Understanding how phenotypic differences between males and females arise from the sex-biased expression of nearly identical genomes can reveal important insights into the biology and evolution of a species. Among Anopheles mosquito species, these phenotypic differences include vectorial capacity, as it is only females that blood feed and thus transmit human malaria. Here, we use RNA-seq data from multiple tissues of four vector species spanning the Anopheles phylogeny to explore the genomic and evolutionary properties of sex-biased genes. We find that, in these mosquitoes, in contrast to what has been found in many other organisms, female-biased genes are more rapidly evolving in sequence, expression, and genic turnover than male-biased genes. Our results suggest that this atypical pattern may be due to the combination of sex-specific life history challenges encountered by females, such as blood feeding. Furthermore, female propensity to mate only once in nature in male swarms likely diminishes sexual selection of post-reproductive traits related to sperm competition among males. We also develop a comparative framework to systematically explore tissue- and sex-specific splicing to document its conservation throughout the genus and identify a set of candidate genes for future functional analyses of sex-specific isoform usage. Finally, our data reveal that the deficit of male-biased genes on the X Chromosomes in Anopheles is a conserved feature in this genus and can be directly attributed to chromosome-wide transcriptional regulation that de-masculinizes the X in male reproductive tissues.

Pubmed
Web of science
Open Access
Yes
Create date
05/09/2017 12:14
Last modification date
09/05/2019 2:43
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