Effects of vaginal progesterone on pain and uterine contractility in patients with threatened abortion before twelve weeks of pregnancy

Details

Serval ID
serval:BIB_E68F8666FB32
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effects of vaginal progesterone on pain and uterine contractility in patients with threatened abortion before twelve weeks of pregnancy
Journal
Annals of the New York Academy of Sciences
Author(s)
Palagiano  A., Bulletti  C., Pace  M. C., D  D. E. Ziegler, Cicinelli  E., Izzo  A.
ISSN
0077-8923
Publication state
Published
Issued date
12/2004
Peer-reviewed
Oui
Volume
1034
Pages
200-10
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Dec
Abstract
Fifty women with previous diagnosis of inadequate luteal phase and threatened abortion underwent a prospective, randomized, double-blind study in one medical center carried out with a parallel trial. The primary objective was to establish the effects of vaginal progesterone (Crinone 8%) in reducing both pain and uterine contractions (UCs). The gel with or without (placebo) vaginal progesterone was administered once a day since the diagnosis of threatened abortion and for 5 days. The efficacy on pain symptom amelioration was evaluated by a 5-score intensity gradation, while the UCs were evaluated by ultrasound. The secondary objective of the study was to evaluate the outcome of the pregnancies. The use of progesterone was effective both on pain relief and on the frequency of the UCs that decreased after 5 days of vaginal progesterone administration (P < 0.005). The evaluation of the ongoing pregnancy and spontaneous abortion in both study groups after 60 days showed that 4 patients of group A and 8 patients of group B miscarried (P < 0.05). In conclusion, patients with threatened abortion benefit from vaginal progesterone by a reduction of UCs and pain. The use of vaginal progesterone improved the outcome of pregnancies complicated by threatened abortion and previous diagnosis of inadequate luteal phase.
Keywords
Abortion, Threatened/*drug therapy Administration, Intravaginal Adult Female Humans Infertility, Female/drug therapy Labor Pain/*drug therapy Luteal Phase Pregnancy Pregnancy Outcome Progesterone/*administration & dosage/*analogs & derivatives Prospective Studies Uterine Contraction/*drug effects Uterus/drug effects
Pubmed
Web of science
Create date
28/02/2008 11:36
Last modification date
20/08/2019 16:09
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