Metabolic syndrome and the risk of cardiovascular disease in older adults.

Details

Serval ID
serval:BIB_E68CDE8EB1C2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Metabolic syndrome and the risk of cardiovascular disease in older adults.
Journal
Journal of the American College of Cardiology
Author(s)
Butler J., Rodondi N., Zhu Y., Figaro K., Fazio S., Vaughan D.E., Satterfield S., Newman A.B., Goodpaster B., Bauer D.C., Holvoet P., Harris T.B., de Rekeneire N., Rubin S., Ding J., Kritchevsky S.B.
Working group(s)
Health ABC Study
ISSN
1558-3597 (Electronic)
ISSN-L
0735-1097
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
47
Number
8
Pages
1595-1602
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
OBJECTIVES: The purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults.
BACKGROUND: The importance of MetSyn as a risk factor has not previously focused on older adults and deserves further study.
METHODS: We studied the impact of MetSyn (38% prevalence) on outcomes in 3,035 participants in the Health, Aging, and Body Composition (Health ABC) study (51% women, 42% black, ages 70 to 79 years).
RESULTS: During a 6-year follow-up, there were 434 deaths overall, 472 coronary events (CE), 213 myocardial infarctions (MI), and 231 heart failure (HF) hospital stays; 59% of the subjects had at least one hospital stay. Coronary events, MI, HF, and overall hospital stays occurred significantly more in subjects with MetSyn (19.9% vs. 12.9% for CE, 9.1% vs. 5.7% for MI, 10.0% vs. 6.1% for HF, and 63.1% vs. 56.1% for overall hospital stay; all p < 0.001). No significant differences in overall mortality was seen; however, there was a trend toward higher cardiovascular mortality (5.1% vs. 3.8%, p = 0.067) and coronary mortality (4.5% vs. 3.2%, p = 0.051) in patients with MetSyn. After adjusting for baseline characteristics, patients with MetSyn were at a significantly higher risk for CE (hazard ratio [HR] 1.56, 95% confidence interval [CI] 1.28 to 1.91), MI (HR 1.51, 95% CI 1.12 to 2.05), and HF hospital stay (HR 1.49, 95% CI 1.10 to 2.00). Women and whites with MetSyn had a higher coronary mortality rate. The CE rate was higher among subjects with diabetes and with MetSyn; those with both had the highest risk.
CONCLUSIONS: Overall, subjects over 70 years are at high risk for cardiovascular events; MetSyn in this group is associated with a significantly greater risk.
Keywords
Aged, Aging, Cardiac Output, Low/etiology, Cardiovascular Diseases/etiology, Cardiovascular Diseases/mortality, Cohort Studies, Coronary Disease/etiology, Diabetes Complications, European Continental Ancestry Group/statistics & numerical data, Female, Hospitalization/statistics & numerical data, Humans, Male, Metabolic Syndrome X/complications, Myocardial Infarction/etiology, Proportional Hazards Models, Risk Assessment, Sex Distribution
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 12:01
Last modification date
20/08/2019 16:09
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