Angiotensin II as an Inducer of Atherosclerosis: Evidence from Mouse Studies

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Ressource 1Download: BIB_E6568726F216.P001.pdf (1505.63 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_E6568726F216
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Angiotensin II as an Inducer of Atherosclerosis: Evidence from Mouse Studies
Journal
Journal of Clinical and Experimental Cardiology
Author(s)
Pellegrin M., Mazzolai L.
ISSN
2155-9880
ISSN-L
2155-9880
Publication state
Published
Issued date
2013
Volume
1
Number
S1
Pages
007
Language
english
Notes
pdf type: review article
Copyright: © 2013 Pellegrin M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Mechanisms responsible for atherosclerotic plaque development, destabilization, and rupture are still largely unknown. Angiotensin II, the main bioactive peptide of renin angiotensin system, has been shown to be critically involved in the pathogenesis of atherosclerosis and vulnerable plaque. Experimental studies in hypercholesterolemic mouse models with high circulating Angiotensin II levels, provide direct evidence that Angiotensin II induces plaque vulnerability partly by 1/ downregulating vascular expression of anti-atherosclerotic genes and/or upregulating expression of pro-atherosclerotic genes, and 2/ skewing the systemic lymphocyte Th1/Th2 balance towards a proinflammatory Th1 response in early disease phase. Further understanding the pro-atherosclerotic mechanisms of Angiotensin II and associated signaling pathways will help to design better therapeutic strategies for reducing the burden of atherosclerotic cardiovascular disease.
Open Access
Yes
Create date
12/02/2014 14:47
Last modification date
20/08/2019 16:09
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