Neuropathie subaiguë, cancers multiples et syndrome de Gougerot-Sjögren: intérêt des anticorps anti-Hu [Subacute neuropathy, multiple cancers, and Gougerot-Sjögren syndrome: contribution of anti-Hu antibody].

Details

Serval ID
serval:BIB_E6395F3786B0
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Neuropathie subaiguë, cancers multiples et syndrome de Gougerot-Sjögren: intérêt des anticorps anti-Hu [Subacute neuropathy, multiple cancers, and Gougerot-Sjögren syndrome: contribution of anti-Hu antibody].
Journal
Revue Neurologique
Author(s)
Auf G., Benyahia B., Orcel B., Beigelman C., Delattre J.Y.
ISSN
0035-3787 (Print)
ISSN-L
0035-3787
Publication state
Published
Issued date
2001
Volume
157
Number
2
Pages
219-221
Language
french
Notes
Publication types: Case Reports ; English Abstract ; Journal Article
Abstract
We report the case of a patient presenting a subacute, predominantly sensory neuropathy. The work up revealed a Sjögren's syndrome and a breast carcinoma. The presence of anti-Hu antibodies, identified by Western Blot using purified recombinant HuD protein, and the absence of the Hu antigen in the breast carcinoma ruled out the responsibility of the Sjögren's syndrome or breast carcinoma. In this context, the most likely diagnosis was a subacute neuropathy associated with small cell lung cancer, which was indeed discovered 3 years later.
Keywords
Aged, Autoantibodies/analysis, Breast Neoplasms/immunology, Breast Neoplasms/pathology, Carcinoma, Small Cell/pathology, Female, Hu Paraneoplastic Encephalomyelitis Antigens, Humans, Lung Neoplasms/immunology, Lung Neoplasms/pathology, Neoplasms, Multiple Primary/complications, Neoplasms, Multiple Primary/diagnosis, Nerve Tissue Proteins/analysis, Nerve Tissue Proteins/immunology, Nervous System Diseases/complications, Nervous System Diseases/diagnosis, RNA-Binding Proteins/analysis, RNA-Binding Proteins/immunology, Sjogren's Syndrome/complications, Sjogren's Syndrome/diagnosis
Pubmed
Create date
31/08/2011 12:46
Last modification date
20/08/2019 16:09
Usage data