Synchronous tumors of the pancreas and the gallbladder: a case report with targeted NGS evaluation.

Details

Serval ID
serval:BIB_E63067455864
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Synchronous tumors of the pancreas and the gallbladder: a case report with targeted NGS evaluation.
Journal
Annals of translational medicine
Author(s)
Sivade A., Sempoux C., Voutsadakis I., Brunel C., Halkic N., Godat S., Duran R., Digklia A.
ISSN
2305-5839 (Print)
ISSN-L
2305-5839
Publication state
Published
Issued date
11/2019
Peer-reviewed
Oui
Volume
7
Number
22
Pages
696
Language
english
Notes
Publication types: Case Reports
Publication Status: ppublish
Abstract
Synchronous tumors of the pancreas and gallbladder are rare and often attributed to an abnormal pancreato-biliary junction, which results in a persistent reflux of pancreatic secretions leading to chronic biliary inflammation. We present the case of a 73-year-old woman with synchronous lesions of the pancreas and gallbladder initially considered as two primary localized cancers and treated with curative intent. At relapse, targeted next generation sequencing (NGS), performed in search of potential therapeutic targets, uncovered the fact that the two lesions appeared to be clonally related. This case illustrates the problem of synchronous lesions of the pancreas and gallbladder. New pathologic assessments with comparative molecular analysis of mutational profiles may be helpful in this context.
Keywords
General Medicine, HER2, Next generation sequencing (NGS), cancer, gallbladder
Pubmed
Web of science
Create date
04/01/2020 11:32
Last modification date
23/01/2020 6:26
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