Childhood epilepsy with neuropsychological regression and continuous spike waves during sleep: epilepsy surgery in a young adult.

Details

Serval ID
serval:BIB_E622E9BF7046
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Childhood epilepsy with neuropsychological regression and continuous spike waves during sleep: epilepsy surgery in a young adult.
Journal
European Journal of Paediatric Neurology
Author(s)
Roulet Perez E., Seeck M., Mayer E., Despland P.A., de Tribolet N., Deonna T.
ISSN
1090-3798
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
2
Number
6
Pages
303-311
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
We describe the case of a man with a history of complex partial seizures and severe language, cognitive and behavioural regression during early childhood (3.5 years), who underwent epilepsy surgery at the age of 25 years. His early epilepsy had clinical and electroencephalogram features of the syndromes of epilepsy with continuous spike waves during sleep and acquired epileptic aphasia (Landau-Kleffner syndrome), which we considered initially to be of idiopathic origin. Seizures recurred at 19 years and presurgical investigations at 25 years showed a lateral frontal epileptic focus with spread to Broca's area and the frontal orbital regions. Histopathology revealed a focal cortical dysplasia, not visible on magnetic resonance imaging. The prolonged but reversible early regression and the residual neuropsychological disorders during adulthood were probably the result of an active left frontal epilepsy, which interfered with language and behaviour during development. Our findings raise the question of the role of focal cortical dysplasia as an aetiology in the syndromes of epilepsy with continuous spike waves during sleep and acquired epileptic aphasia.
Keywords
Adult, Aphasia, Disease Progression, Electroencephalography, Epilepsy, Complex Partial, Frontal Lobe, Humans, Landau-Kleffner Syndrome, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Recurrence, Regression (Psychology), Sleep, Tomography, Emission-Computed, Single-Photon
Pubmed
Create date
25/01/2008 11:40
Last modification date
20/08/2019 16:09
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