Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis in middle-aged adults.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: author
Serval ID
serval:BIB_E61A744996D4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis in middle-aged adults.
Journal
Nephrology, Dialysis, Transplantation
Author(s)
Rodondi N., Yerly P., Gabriel A., Riesen W.F., Burnier M., Paccaud F., Bovet P.
ISSN
0931-0509 (Print)
ISSN-L
0931-0509
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
22
Number
4
Pages
1107-1114
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND: Cystatin C, a marker of renal function, has been shown to be an independent predictor of cardiovascular disease (CVD) in older adults, but few data are available in middle-aged adults. Moreover, no study has compared cystatin C and microalbuminuria as risk factors for CVD outcomes in middle-aged adults, and it is not known whether cystatin C is related to an early stage of atherosclerosis.
METHODS: We evaluated the relationships between serum creatinine, estimated glomerular filtration rate (GFR), serum cystatin C (all divided into tertiles), microalbuminuria and carotid atherosclerosis in a population-based random sample of 523 adults aged 35-64 years from the Seychelles (Indian Ocean). GFR was estimated using the modification of diet in renal disease (MDRD) equation. Intima-media thickness (IMT) was assessed by B-mode ultrasound.
RESULTS: The mean age of the study sample was 52 years, and 55% were women. Carotid IMT was higher in participants with microalbuminuria (802 vs 732 microm, P<0.001) and was inversely associated with GFR tertiles (from 728 to 809 microm, P for trend=0.002). IMT was not associated with cystatin C or creatinine (P for trend=0.10 and 0.16, respectively). In multivariate analyses adjusted for cardiovascular risk factors, the association between microalbuminuria and IMT remained (P=0.047), while the association between GFR and IMT disappeared (P for trend=0.33).
CONCLUSIONS: Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis beyond traditional cardiovascular risk factors among middle-aged adults. Cystatin C does not have a stronger relationship with carotid atherosclerosis in middle-aged adults than creatinine.
Keywords
Adult, Age Factors, Albuminuria, Carotid Artery Diseases/blood, Carotid Artery Diseases/physiopathology, Creatinine/blood, Cross-Sectional Studies, Cystatin C, Cystatins/blood, Female, Glomerular Filtration Rate/physiology, Health Surveys, Humans, Kidney/physiopathology, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Risk Factors, Seychelles, Tunica Intima/pathology, Tunica Intima/ultrasonography
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 14:57
Last modification date
20/08/2019 16:09
Usage data