Expression and function of bactericidal/permeability-increasing protein in human genital tract epithelial cells

Details

Serval ID
serval:BIB_E60C2A97FEBF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Expression and function of bactericidal/permeability-increasing protein in human genital tract epithelial cells
Journal
Journal of Infectious Diseases
Author(s)
Canny  G. O., Trifonova  R. T., Kindelberger  D. W., Colgan  S. P., Fichorova  R. N.
ISSN
0022-1899
Publication state
Published
Issued date
08/2006
Peer-reviewed
Oui
Volume
194
Number
4
Pages
498-502
Notes
Evaluation Studies
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't --- Old month value: Aug 15
Abstract
Genital tract epithelia regularly encounter and adapt to the existence of bacterial pathogens. This study provides evidence that the endocervical and ectocervical epithelia of the human female genital tract express bactericidal/permeability-increasing protein (BPI). The constitutive expression of BPI was restricted to cell-bound protein and unaffected by human papillomavirus type 16/E6E7 immortalization and proinflammatory cytokine stimulation. Epithelial BPI was, in part, responsible for killing a commensal strain of Escherichia coli. The results of the present study suggest that BPI is tightly regulated and functionally expressed by epithelial cells in the female reproductive tract and may play a role in regulating bacterial colonization in the genital mucosa.
Keywords
Antimicrobial Cationic Peptides/*metabolism/pharmacology Blood Proteins/*metabolism/pharmacology Cells, Cultured Cervix Uteri/*cytology Epithelial Cells/*metabolism Escherichia coli/drug effects Female Humans Immunohistochemistry Inflammation/metabolism/microbiology/pathology Membrane Proteins/*metabolism/pharmacology
Pubmed
Web of science
Open Access
Yes
Create date
18/01/2008 12:11
Last modification date
20/08/2019 16:09
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