Inflammatory biomarkers in Alzheimer's disease plasma.

Details

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_E5F2C092E354
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inflammatory biomarkers in Alzheimer's disease plasma.
Journal
Alzheimer's & dementia
Author(s)
Morgan A.R., Touchard S., Leckey C., O'Hagan C., Nevado-Holgado A.J., Barkhof F., Bertram L., Blin O., Bos I., Dobricic V., Engelborghs S., Frisoni G., Frölich L., Gabel S., Johannsen P., Kettunen P., Kłoszewska I., Legido-Quigley C., Lleó A., Martinez-Lage P., Mecocci P., Meersmans K., Molinuevo J.L., Peyratout G., Popp J., Richardson J., Sala I., Scheltens P., Streffer J., Soininen H., Tainta-Cuezva M., Teunissen C., Tsolaki M., Vandenberghe R., Visser P.J., Vos S., Wahlund L.O., Wallin A., Westwood S., Zetterberg H., Lovestone S., Morgan B.P.
Working group(s)
NIMA Consortium, Annex: NIMA-Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer's Disease
Contributor(s)
Bullmore E.T., Bhatti J., Chamberlain S.J., Correia M.M., Crofts A.L., Dickinson A., Foster A.C., Kitzbichler M.G., Knight C., Lynall M.E., Maurice C., O'Donnell C., Pointon L.J., St George Hyslop P., Turner L., Vertes P., Widmer B., Williams G.B., Morgan B.P., Leckey C.A., Morgan A.R., O'Hagan C., Touchard S., Cavanagh J., Deith C., Farmer S., McClean J., McColl A., McPherson A., Scouller P., Sutherland M., Boddeke HWGM, Richardson J.C., Khan S., Murphy P., Parker C.A., Patel J., Jones D., de Boer P., Kemp J., Drevets W.C., Nye J.S., Wittenberg G., Isaac J., Bhattacharya A., Carruthers N., Kolb H., Pariante C.M., Turkheimer F., Barker G.J., Byrom H., Cash D., Cattaneo A., Gee A., Hastings C., Mariani N., McLaughlin A., Mondelli V., Nettis M., Nikkheslat N., Randall K., Sheridan H., Simmons C., Singh N., Van Loo V., Vicente-Rodriguez M., Wood T.C., Worrell C., Zajkowska Z., Plath N., Egebjerg J., Eriksson H., Gastambide F., Adams K.H., Jeggo R., Thomsen C., Pederson J.T., Campbell B., Möller T., Nelson B., Zorn S., O'Connor J., Attenburrow M.J., Baird A., Benjamin J., Clare S., Cowen P., Huang I.D., Hurley S., Jones H., Lovestone S., Mada F., Nevado-Holgado A., Oladejo A., Ribe E., Smith K., Vyas A., Hughes Z., Balice-Gordon R., Duerr J., Piro J.R., Sporn J., Perry V.H., Cleal M., Fryatt G., Gomez-Nicola D., Mancuso R., Reynolds R., Harrison N.A., Cercignani M., Clarke C.L., Hoskins E., Kohn C., Murray R., Wilcock L., Wlazly D., Mount H.
ISSN
1552-5279 (Electronic)
ISSN-L
1552-5260
Publication state
Published
Issued date
06/2019
Peer-reviewed
Oui
Volume
15
Number
6
Pages
776-787
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers.
A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL; 259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed.
Ten analytes showed significant intergroup differences. Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APOε4 adjusted, optimally differentiated AD and CTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Two analytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71).
Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation.
Keywords
Aged, Alzheimer Disease/blood, Alzheimer Disease/diagnosis, Amyloid beta-Peptides/blood, Biomarkers/blood, Cognitive Dysfunction/blood, Cognitive Dysfunction/diagnosis, Cohort Studies, Complement Factor B, Complement Factor H, Humans, Inflammation, Internationality, Prognosis, Alzheimer's disease, Biomarker, Complement, Plasma
Pubmed
Web of science
Open Access
Yes
Create date
07/05/2019 14:51
Last modification date
07/07/2020 5:20
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