Gaseous second messengers in vertebrate olfaction

Details

Serval ID
serval:BIB_E5C70AA550B6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Gaseous second messengers in vertebrate olfaction
Journal
Journal of Neurobiology
Author(s)
Broillet  M. C., Firestein  S.
ISSN
0022-3034 (Print)
Publication state
Published
Issued date
05/1996
Volume
30
Number
1
Pages
49-57
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: May
Abstract
Gaseous monoxides such as nitric oxide (NO) and carbon monoxide (CO) are now recognized as important messengers in the nervous system. The enzymes generating these compounds are highly expressed in the olfactory system, including the epithelium and the main and accessory bulbs. Although the physiological roles of these molecules is still not entirely clear, some important new data has recently emerged. Alternate pathways for NO action, possible interactions between NO, CO, and intermediate proteins, and evidence suggestive of important roles for these molecules in development and regeneration are reviewed here. Of particular interest is the possible modulatory role of NO or CO in the transduction process, an area in which there has been an explosive growth in new data. Although it is clear that NO and CO are integral to the functioning of the olfactory system, it is equally obvious that many of the potential roles have yet to be clearly defined.
Keywords
Animals Carbon Monoxide/*metabolism Gases/*metabolism Humans NADPH Dehydrogenase/analysis Nitric Oxide/*physiology Nitric Oxide Synthase/analysis Olfactory Mucosa/chemistry/*physiology Second Messenger Systems/*physiology Vertebrates/*physiology
Pubmed
Web of science
Create date
24/01/2008 11:01
Last modification date
20/08/2019 16:09
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