Deficits of brainstem and spinal cord functions after neonatal hypoxia-ischemia in mice.

Details

Serval ID
serval:BIB_E5BCC69D754D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Deficits of brainstem and spinal cord functions after neonatal hypoxia-ischemia in mice.
Journal
Pediatric Research
Author(s)
Bellot B., Peyronnet-Roux J., Gire C., Simeoni U., Vinay L., Viemari J.C.
ISSN
1530-0447 (Electronic)
ISSN-L
0031-3998
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
75
Number
6
Pages
723-730
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
BACKGROUND: Perinatal cerebral hypoxia-ischemia (HI) can lead to severe neurodevelopmental disorders. Studies in humans and animal models mainly focused on cerebral outcomes, and little is known about the mechanisms that may affect the brainstem and the spinal cord. Dysfunctions of neuromodulatory systems, such as the serotonergic (5-HT) projections, critical for the development of neural networks, have been postulated to underlie behavioral and motor deficits, as well as metabolic changes.
METHODS: The aim of this study was to investigate brainstem and spinal cord functions by means of plethysmography and sensorimotor tests in a neonatal Rice-Vanucci model of HI in mice. We also evaluated bioaminergic contents in central regions dedicated to the motor control of autonomic functions.
RESULTS: Mice with cerebral infarct expressed motor disturbances and had a lower body weight and a decreased respiratory frequency than SHAM, suggesting defects of brainstem neural network involved in the motor control of feeding, suckling, swallowing, and respiration. Moreover, our study revealed changes of monoamine and amino acid contents in the brainstem and the spinal cord of HI mice.
CONCLUSION: Our results suggest that monoaminergic neuromodulation plays an important role in the physiopathology of HI brain injury that may represent a good therapeutic target.
Keywords
Amino Acids/metabolism, Animals, Animals, Newborn, Biogenic Monoamines/metabolism, Body Weight, Brain Stem/physiopathology, Hypoxia-Ischemia, Brain/physiopathology, Mice, Plethysmography, Postural Balance/physiology, Receptors, Neurotransmitter/metabolism, Spinal Cord/physiopathology, Statistics, Nonparametric
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2015 14:51
Last modification date
20/08/2019 16:09
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