Distribution of plasma levels of adiponectin and leptin in an adult Caucasian population.

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State: Public
Version: author
Serval ID
serval:BIB_E5B4439ABC97
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Distribution of plasma levels of adiponectin and leptin in an adult Caucasian population.
Journal
Clinical endocrinology
Author(s)
Marques-Vidal P., Bochud M., Paccaud F., Mooser V., Waeber G., Vollenweider P.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Publication state
Published
Issued date
01/2010
Peer-reviewed
Oui
Volume
72
Number
1
Pages
38-46
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Little is known regarding the distribution and the determinants of leptin and adiponectin levels in the general population.
Cross-sectional study.
Women (3004) and men (2552) aged 35-74 living in Lausanne, Switzerland.
Plasma levels of leptin and adiponectin (ELISA measurement).
Women had higher leptin and adiponectin levels than men. In both genders, leptin and adiponectin levels increased with age. After adjusting for fat mass, leptin levels were significantly and negatively associated with age in women: 18.1 +/- 0.3, 17.1 +/- 0.3, 16.7 +/- 0.3 and 15.5 +/- 0.4 ng/ml (adjusted mean +/- SE) for age groups [35-44], [45-54], [55-64] and [65-75], respectively, P < 0.001. A similar but nonsignificant trend was also found in men. Conversely, the age-related increase of adiponectin was unrelated to body fat in both genders. Post-menopausal women had higher leptin and adiponectin levels than premenopausal women, independently of hormone replacement therapy. Although body fat mass was associated with leptin and adiponectin, the associations were stronger with body mass index (BMI), waist and hip in both genders. Finally, after adjusting for age and anthropometry, no relationships were found between leptin or adiponectin levels with alcohol, caffeine consumption and physical activity, whereas smoking and diabetes decreased leptin and adiponectin levels in women only.
The age-related increase in leptin levels is attributable to changes in fat mass in women and probably also in men. Leptin and adiponectin levels are more related to BMI than to body fat mass. The effects of smoking and diabetes appear to be gender-specific.

Keywords
Adiponectin/blood, Adipose Tissue/anatomy & histology, Adult, Age Factors, Aged, Body Mass Index, Cross-Sectional Studies, European Continental Ancestry Group/statistics & numerical data, Female, Humans, Leptin/blood, Life Style, Male, Menopause/blood, Middle Aged, Population, Switzerland
Pubmed
Web of science
Create date
06/08/2009 13:48
Last modification date
20/08/2019 16:09
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