Somatosensory map expansion and altered processing of tactile inputs in a mouse model of fragile X syndrome.

Details

Serval ID
serval:BIB_E5ACB8D50C81
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Somatosensory map expansion and altered processing of tactile inputs in a mouse model of fragile X syndrome.
Journal
Neurobiology of disease
Author(s)
Juczewski K., von Richthofen H., Bagni C., Celikel T., Fisone G., Krieger P.
ISSN
1095-953X (Electronic)
ISSN-L
0969-9961
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
96
Pages
201-215
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Fragile X syndrome (FXS) is a common inherited form of intellectual disability caused by the absence or reduction of the fragile X mental retardation protein (FMRP) encoded by the FMR1 gene. In humans, one symptom of FXS is hypersensitivity to sensory stimuli, including touch. We used a mouse model of FXS (Fmr1 KO) to study sensory processing of tactile information conveyed via the whisker system. In vivo electrophysiological recordings in somatosensory barrel cortex showed layer-specific broadening of the receptive fields at the level of layer 2/3 but not layer 4, in response to whisker stimulation. Furthermore, the encoding of tactile stimuli at different frequencies was severely affected in layer 2/3. The behavioral effect of this broadening of the receptive fields was tested in the gap-crossing task, a whisker-dependent behavioral paradigm. In this task the Fmr1 KO mice showed differences in the number of whisker contacts with platforms, decrease in the whisker sampling duration and reduction in the whisker touch-time while performing the task. We propose that the increased excitability in the somatosensory barrel cortex upon whisker stimulation may contribute to changes in the whisking strategy as well as to other observed behavioral phenotypes related to tactile processing in Fmr1 KO mice.

Keywords
Afferent Pathways/pathology, Animals, Disease Models, Animal, Fragile X Mental Retardation Protein/genetics, Fragile X Mental Retardation Protein/metabolism, Fragile X Syndrome/complications, Fragile X Syndrome/genetics, Fragile X Syndrome/pathology, Humans, Locomotion/genetics, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Reaction Time/genetics, Somatosensory Cortex/pathology, Touch/physiology, Vibrissae/innervation, Barrel cortex, Behavior, FMRP, Fmr1 KO, Fragile X syndrome, Gap-crossing task, Hyperexcitation, In vivo electrophysiology, Sensory processing, Whisker system
Pubmed
Web of science
Create date
23/09/2016 18:27
Last modification date
20/08/2019 16:09
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