Inhibition of fas death signals by FLIPs.

Details

Serval ID
serval:BIB_E59DFB495E51
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Inhibition of fas death signals by FLIPs.
Journal
Current Opinion in Immunology
Author(s)
Tschopp J., Irmler M., Thome M.
ISSN
0952-7915 (Print)
ISSN-L
0952-7915
Publication state
Published
Issued date
1998
Volume
10
Number
5
Pages
552-558
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The death receptor Fas is a member of the tumor necrosis factor receptor family; upon interaction with its ligand it efficiently activates caspases and induces apoptosis. Despite abundant Fas surface expression, however, Fas death-signals are frequently interrupted. Many viruses express antiapoptotic proteins, including caspase inhibitors, Bcl-2 homologues and death-effector-domain-containing proteins that are termed FLIPs (FLICE [Fas-associated death-domain-like IL-1beta-converting enzyme]-inhibitory proteins). Cellular homologues of these inhibitors have been identified. Cellular FLIPs structurally resemble caspase-8 except that they lack proteolytic activity. FLIPs are highly expressed in tumor cells, T lymphocytes and healthy, but not injured, myocytes; this suggests a critical role of FLIPs as endogenous modulators of apoptosis.
Keywords
Animals, Antigens, CD95/physiology, Apoptosis, CASP8 and FADD-Like Apoptosis Regulating Protein, Carrier Proteins/physiology, Caspase Inhibitors, Caspases/physiology, Fas Ligand Protein, Humans, Intracellular Signaling Peptides and Proteins, Membrane Glycoproteins/physiology, Proto-Oncogene Proteins c-bcl-2/physiology
Pubmed
Web of science
Create date
24/01/2008 15:18
Last modification date
20/08/2019 16:09
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