Hypertension. Angio-oedème sous inhibition de l'enzyme de conversion de l'angiotensine et de la dipeptidyl-peptidase-4 [Angioedema during ACE and DPP-4 inhibition]

Details

Serval ID
serval:BIB_E59B27F760F0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hypertension. Angio-oedème sous inhibition de l'enzyme de conversion de l'angiotensine et de la dipeptidyl-peptidase-4 [Angioedema during ACE and DPP-4 inhibition]
Journal
Revue Médicale Suisse
Author(s)
Waeber B., Buclin T., Grouzmann E.
ISSN
1660-9379[print], 1660-9379[linking]
Publication state
Published
Issued date
2010
Volume
6
Number
231
Pages
28-31
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Abstract
Angioedema is a rare side effect of angiotensin converting enzyme (ACE) inhibitors. Its cause is probably related to the accumulation of bradykinin and substance P, i.e. two proinflammatory peptides normally inactivated by ACE. Angioedema occurs most of the time at the early phase of treatment, but may also develop during long-term treatment. It might involve the gastro-intestinal tract, leading to abdominal pain, vomiting and/or diarrhea, as well as pancreatitis. Dipeptidyl-ptidase-4 (DPP-4) is another enzyme allowing the degradation of bradykinin and substance P. Co-administering an ACE inhibitor and a DPP-4 inhibitor (as an antidiabetic agent) increases significantly the risk of angioedema.
Keywords
Angioedema/chemically induced, Angiotensin-Converting Enzyme Inhibitors/adverse effects, Antigens, CD26/antagonists & inhibitors, Enzyme Inhibitors/adverse effects, Humans
Pubmed
Create date
28/06/2010 15:42
Last modification date
20/08/2019 16:08
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