The Reduction of Visceral Adipose Tissue after Roux-en-Y Gastric Bypass Is more Pronounced in Patients with Impaired Glucose Metabolism.

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Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Reduction of Visceral Adipose Tissue after Roux-en-Y Gastric Bypass Is more Pronounced in Patients with Impaired Glucose Metabolism.
Journal
Obesity surgery
Author(s)
Favre L., Marino L., Roth A., Acierno J., Hans D., Demartines N., Pitteloud N., Suter M., Collet T.H.
ISSN
1708-0428 (Electronic)
ISSN-L
0960-8923
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
28
Number
12
Pages
4006-4013
Language
english
Notes
Publication types: Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Visceral adipose tissue (VAT) is associated with cardiometabolic risk factors and insulin resistance. The physiological mechanisms underlying the benefits of Roux-en-Y gastric bypass surgery (RYGB) on glucose metabolism remain incompletely understood. The impact of RYGB on VAT was assessed among three groups of patients stratified by their glucose tolerance before surgery.
Forty-four obese women were categorized into normoglycemia (n = 21), impaired glucose tolerance (IGT, n = 18) and diabetes (n = 5) before surgery. Body composition measured by dual-energy X-ray absorptiometry (DXA) was performed before surgery, 6 months and 12 months after.
The three groups had comparable mean age (mean 38.6 ± SD 9.9) and BMI at baseline (41.9 ± 4.3 kg/m <sup>2</sup> ). After 12 months, total weight loss (mean 35.1% ± 7.5) and excess weight loss (91.1% ± 25.1) were similar between groups. Pre-surgery mean VAT was significantly higher in diabetes (mean 2495 ± 616 g) than in normoglycemia (1750 ± 617 g, p = 0.02). The percentage of VAT to total body fat was significantly higher in diabetes (mean 4.4% ± 0.9) compared to normoglycemia (2.9% ± 0.8, p = 0.003). Twelve months after surgery, VAT loss was significantly greater among patients with diabetes (mean 1927 ± 413 g) compared to normoglycemia (1202 ± 450, p = 0.009).
RYGB leads to important VAT loss, and this loss is greater in patients with diabetes prior to surgery. As VAT is associated with insulin resistance, this reduction may account for the profound impact of this surgery on glucose metabolism.
Keywords
Absorptiometry, Photon, Adult, Biomarkers/metabolism, Body Composition, Diabetes Mellitus, Type 2/complications, Diabetes Mellitus, Type 2/metabolism, Female, Follow-Up Studies, Gastric Bypass, Glucose/metabolism, Glucose Intolerance/metabolism, Humans, Insulin Resistance, Intra-Abdominal Fat/metabolism, Middle Aged, Obesity, Morbid/complications, Obesity, Morbid/metabolism, Obesity, Morbid/surgery, Prospective Studies, Risk Factors, Treatment Outcome, Weight Loss/physiology, Bariatric surgery, Dual-energy X-ray absorptiometry (DXA), Roux-en-Y gastric bypass, Type 2 diabetes, Visceral adipose tissue
Pubmed
Web of science
Open Access
Yes
Create date
17/08/2018 21:33
Last modification date
26/10/2019 6:09
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