FXYD proteins: new regulators of Na-K-ATPase

Details

Serval ID
serval:BIB_E591BF2AFD55
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
FXYD proteins: new regulators of Na-K-ATPase
Journal
American Journal of Physiology. Renal Physiology
Author(s)
Geering  K.
ISSN
0363-6127 (Print)
Publication state
Published
Issued date
02/2006
Volume
290
Number
2
Pages
F241-50
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Feb
Abstract
FXYD proteins belong to a family of small-membrane proteins. Recent experimental evidence suggests that at least five of the seven members of this family, FXYD1 (phospholemman), FXYD2 (gamma-subunit of Na-K-ATPase), FXYD3 (Mat-8), FXYD4 (CHIF), and FXYD7, are auxiliary subunits of Na-K-ATPase and regulate Na-K-ATPase activity in a tissue- and isoform-specific way. These results highlight the complexity of the regulation of Na+ and K+ handling by Na-K-ATPase, which is necessary to ensure appropriate tissue functions such as renal Na+ reabsorption, muscle contractility, and neuronal excitability. Moreover, a mutation in FXYD2 has been linked to cases of human hypomagnesemia, indicating that perturbations in the regulation of Na-K-ATPase by FXYD proteins may be critically involved in pathophysiological states. A better understanding of this novel regulatory mechanism of Na-K-ATPase should help in learning more about its role in pathophysiological states. This review summarizes the present knowledge of the role of FXYD proteins in the modulation of Na-K-ATPase as well as of other proteins, their regulation, and their structure-function relationship.
Keywords
Amino Acid Sequence Animals Humans Membrane Proteins/*chemistry/*physiology Molecular Sequence Data Na(+)-K(+)-Exchanging ATPase/*chemistry/*physiology Nephrons/metabolism Protein Subunits Sequence Homology, Amino Acid Structure-Activity Relationship
Pubmed
Web of science
Create date
24/01/2008 12:28
Last modification date
20/08/2019 16:08
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