Effect of short-term creatine supplementation on renal responses in men.

Details

Serval ID
serval:BIB_E591BC945DD5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of short-term creatine supplementation on renal responses in men.
Journal
European Journal of Applied Physiology and Occupational Physiology
Author(s)
Poortmans J.R., Auquier H., Renaut V., Durussel A., Saugy M., Brisson G.R.
ISSN
0301-5548
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
76
Number
6
Pages
566-567
Language
english
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
There is an increasing utilisation of oral creatine (Cr) supplementation among athletes who hope to enhance their performance but it is not known if this ingestion has any detrimental effect on the kidney. Five healthy men ingested either a placebo or 20 g of creatine monohydrate per day for 5 consecutive days. Blood samples and urine collections were analysed for Cr and creatinine (Crn) determination after each experimental session. Total protein and albumin urine excretion rates were also determined. Oral Cr supplementation had a significant incremental impact on arterial content (3.7 fold) and urine excretion rate (90 fold) of this compound. In contrast, arterial and urine Crn values were not affected by the Cr ingestion. The glomerular filtration rate (Crn clearance) and the total protein and albumin excretion rates remained within the normal range. In conclusion, this investigation showed that short-term oral Cr supplementation does not appear to have any detrimental effect on the renal responses of healthy men.
Keywords
Adult, Albuminuria, Arteries, Creatine, Creatinine, Glomerular Filtration Rate, Humans, Kidney, Male, Proteinuria
Pubmed
Web of science
Create date
28/03/2009 12:46
Last modification date
20/08/2019 16:08
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