Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes

Details

Serval ID
serval:BIB_E55E8D3B020C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes
Journal
Lancet
Author(s)
Ruiz  J., Blanche  H., James  R. W., Garin  M. C., Vaisse  C., Charpentier  G., Cohen  N., Morabia  A., Passa  P., Froguel  P.
ISSN
0140-6736
Publication state
Published
Issued date
09/1995
Volume
346
Number
8979
Pages
869-72
Notes
96016242
0140-6736
Journal Article --- Old month value: Sep 30 --- Old uritopublisher value: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7564671
Abstract
Paraoxonase is a high-density-lipoprotein-associated enzyme capable of hydrolysing lipid peroxides. Thus it might protect lipoproteins from oxidation. It has two isoforms, which arise from a glutamine (A isoform) to arginine (B isoform) interchange at position 192. The relevance of this polymorphism to coronary heart disease (CHD) in non-insulin-dependent diabetic patients was investigated in case-control study. Of the 434 patients, 171 had confirmed coronary artery disease; the other 263 had no history of such disease. The B allele and AB+BB genotypes were associated with an increased risk of coronary heart disease. Compared with subjects homozygous for the A allele (AA genotype), the odds ratio of CHD for subjects homozygous for the B allele was 2.5 (95% CI 1.2-5.3) and that for those heterozygous for the B allele was 1.6 (95% CI 1.1-2.4), suggesting a codominant effect on cardiovascular risk. When subjected to multivariate analysis, the B allele remained significantly associated with CHD (odds ratio 1.94, p = 0.03). The paraoxonase gene polymorphism is thus an independent cardiovascular risk factor in non-insulin-dependent diabetic patients. A possible explanation for this finding is that activity of the paraoxonase B isotype does not protect well against lipid oxidation, a major atherogenic pathway.
Keywords
Arginine Case-Control Studies Coronary Disease/complications/*enzymology/genetics Diabetes Mellitus, Non-Insulin-Dependent/*complications/*enzymology Esterases/*genetics/metabolism Female Genotype Glutamine Human Male Middle Age Polymorphism (Genetics) Regression Analysis Risk Factors Support, Non-U.S. Gov't
Pubmed
Web of science
Create date
03/03/2008 15:15
Last modification date
20/08/2019 16:08
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