Managing the highly sensitized transplant recipient and B cell tolerance

Details

Serval ID
serval:BIB_E54E9A74D02A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Managing the highly sensitized transplant recipient and B cell tolerance
Journal
Current Opinion in Immunology
Author(s)
Baid  S., Saidman  S. L., Tolkoff-Rubin  N., Williams  W. W., Delmonico  F. L., Cosimi  A. B., Pascual  M.
ISSN
0952-7915
Publication state
Published
Issued date
10/2001
Peer-reviewed
Oui
Volume
13
Number
5
Pages
577-81
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Abstract
The detection of anti-donor-HLA antibodies in a renal allograft recipient's serum, either at the time of or after transplantation, is usually associated with specific antibody-mediated clinical syndromes. These can be divided temporally into three categories: hyperacute rejection, acute humoral rejection and chronic humoral rejection. With the identification of new immunosuppressive drug combinations, more-effective control of alloantibody production has been recently achieved in humans. Thus, prevention and/or treatment of antibody-mediated allograft injury are now possible. Ultimately, the induction of mixed hematopoietic chimerism may allow us to overcome the problem of allosensitization and accept an allograft without chronic immunosuppression.
Keywords
Animals B-Lymphocytes/*immunology HLA Antigens/*immunology Humans Immunization/adverse effects Immunosuppressive Agents/*therapeutic use Isoantibodies/biosynthesis Transplantation Tolerance/*immunology
Pubmed
Web of science
Create date
29/01/2008 13:53
Last modification date
20/08/2019 16:08
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