Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes.

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Serval ID
serval:BIB_E53E9BA4FA49
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes.
Journal
Pflügers Archiv
Author(s)
Rougier J.S., Muller O., Berger S., Centeno G., Schütz G., Firsov D., Abriel H.
ISSN
0031-6768
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
456
Number
2
Pages
407-412
Language
english
Abstract
Despite the fact that mineralocorticoid receptor (MR) antagonist drugs such as spironolactone and eplerenone reduce the mortality in heart failure patients, there is, thus far, no unambiguous demonstration of a functional role of MR in cardiac cells. The aim of this work was to investigate the activation pathway(s) mediating corticosteroid-induced up-regulation of cardiac calcium current (ICa). In this study, using neonatal cardiomyocytes from MR or glucocorticoid receptor (GR) knockout (KO) mice, we show that MR is essential for corticosteroid-induced up-regulation of ICa. This study provides the first direct and unequivocal evidence for MR function in the heart.
Keywords
Adrenal Cortex Hormones, Aldosterone, Animals, Animals, Newborn, Calcium Channels, L-Type, Cells, Cultured, Corticosterone, Dose-Response Relationship, Drug, Mice, Mice, Knockout, Myocytes, Cardiac, Patch-Clamp Techniques, RNA, Messenger, Receptors, Glucocorticoid, Receptors, Mineralocorticoid
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2009 22:13
Last modification date
01/10/2019 6:20
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