Novel T2 Mapping for Evaluating Cervical Cancer Features by Providing Quantitative T2 Maps and Synthetic Morphologic Images: A Preliminary Study.
Details
Serval ID
serval:BIB_E5308E8C570D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Novel T2 Mapping for Evaluating Cervical Cancer Features by Providing Quantitative T2 Maps and Synthetic Morphologic Images: A Preliminary Study.
Journal
Journal of magnetic resonance imaging
ISSN
1522-2586 (Electronic)
ISSN-L
1053-1807
Publication state
Published
Issued date
12/2020
Peer-reviewed
Oui
Volume
52
Number
6
Pages
1859-1869
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
The application value of T <sub>2</sub> mapping in evaluating cervical cancer (CC) features remains unclear.
To investigate the role of T <sub>2</sub> values in evaluating CC classification, grade, and lymphovascular space invasion (LVSI) in comparison to apparent diffusion coefficient (ADC), and to compare synthetic T <sub>2</sub> -weighted (T <sub>2</sub> W) images calculated from T <sub>2</sub> values to conventional T <sub>2</sub> W images for CC staging.
Retrospective.
Sixty-three patients with histopathologically confirmed CC.
3T, conventional T <sub>2</sub> W turbo spin-echo, diffusion-weighted echo-planar, and accelerated T <sub>2</sub> mapping sequence.
T <sub>2</sub> and ADC values between different pathological features of CC were compared. The diagnostic accuracies of conventional and synthetic T <sub>2</sub> W images in staging were also compared.
Parameters were compared using an independent t-test, Wilcoxon signed-rank test, and the chi-square test. Receiver operating characteristic analysis was performed.
The T <sub>2</sub> values varied significantly between well/moderately differentiated and poorly differentiated tumors ([92.8 ± 9.5 msec] vs. [83.8 ± 9.5 msec], P < 0.05) and between LVSI-positive and LVSI-negative CC ([82.2 ± 8.2 msec] vs. [93.9 ± 9.1 msec], P < 0.05). The ADC values showed a significant difference for grade ([0.76 ± 0.10 × 10 <sup>-3</sup> mm <sup>2</sup> /s] vs. [0.65 ± 0.11 × 10 <sup>-3</sup> mm <sup>2</sup> /s], P < 0.05) and no difference for LVSI status ([0.71 ± 0.11× 10 <sup>-3</sup> mm <sup>2</sup> /s] vs. [0.73 ± 0.12× 10 <sup>-3</sup> mm <sup>2</sup> /s], P = 0.472). There was no significant difference in T <sub>2</sub> and ADC values between squamous cell carcinoma and adenocarcinoma (P = 0.378 and P = 0.661, respectively). In MRI staging, the conventional and synthetic T <sub>2</sub> W images resulted in a similar accuracy (71% vs. 68%, P = 0.698).
The accelerated T <sub>2</sub> mapping sequence may facilitate grading and staging of CC by providing quantitative T <sub>2</sub> maps and synthetic T <sub>2</sub> W images in one acquisition. T <sub>2</sub> values may be superior to ADC in predicting LVSI.
2 TECHNICAL EFFICACY STAGE: 2 J. MAGN. RESON. IMAGING 2020;52:1859-1869.
To investigate the role of T <sub>2</sub> values in evaluating CC classification, grade, and lymphovascular space invasion (LVSI) in comparison to apparent diffusion coefficient (ADC), and to compare synthetic T <sub>2</sub> -weighted (T <sub>2</sub> W) images calculated from T <sub>2</sub> values to conventional T <sub>2</sub> W images for CC staging.
Retrospective.
Sixty-three patients with histopathologically confirmed CC.
3T, conventional T <sub>2</sub> W turbo spin-echo, diffusion-weighted echo-planar, and accelerated T <sub>2</sub> mapping sequence.
T <sub>2</sub> and ADC values between different pathological features of CC were compared. The diagnostic accuracies of conventional and synthetic T <sub>2</sub> W images in staging were also compared.
Parameters were compared using an independent t-test, Wilcoxon signed-rank test, and the chi-square test. Receiver operating characteristic analysis was performed.
The T <sub>2</sub> values varied significantly between well/moderately differentiated and poorly differentiated tumors ([92.8 ± 9.5 msec] vs. [83.8 ± 9.5 msec], P < 0.05) and between LVSI-positive and LVSI-negative CC ([82.2 ± 8.2 msec] vs. [93.9 ± 9.1 msec], P < 0.05). The ADC values showed a significant difference for grade ([0.76 ± 0.10 × 10 <sup>-3</sup> mm <sup>2</sup> /s] vs. [0.65 ± 0.11 × 10 <sup>-3</sup> mm <sup>2</sup> /s], P < 0.05) and no difference for LVSI status ([0.71 ± 0.11× 10 <sup>-3</sup> mm <sup>2</sup> /s] vs. [0.73 ± 0.12× 10 <sup>-3</sup> mm <sup>2</sup> /s], P = 0.472). There was no significant difference in T <sub>2</sub> and ADC values between squamous cell carcinoma and adenocarcinoma (P = 0.378 and P = 0.661, respectively). In MRI staging, the conventional and synthetic T <sub>2</sub> W images resulted in a similar accuracy (71% vs. 68%, P = 0.698).
The accelerated T <sub>2</sub> mapping sequence may facilitate grading and staging of CC by providing quantitative T <sub>2</sub> maps and synthetic T <sub>2</sub> W images in one acquisition. T <sub>2</sub> values may be superior to ADC in predicting LVSI.
2 TECHNICAL EFFICACY STAGE: 2 J. MAGN. RESON. IMAGING 2020;52:1859-1869.
Keywords
Carcinoma, Squamous Cell, Diffusion Magnetic Resonance Imaging, Female, Humans, Magnetic Resonance Imaging, Retrospective Studies, Uterine Cervical Neoplasms/diagnostic imaging, T2 mapping, apparent diffusion coefficient, cervical cancer, lymphovascular space invasion, magnetic resonance imaging, pathological grade
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Web of science
Create date
15/09/2020 11:29
Last modification date
16/04/2024 7:11
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