Escalating incidence of eosinophilic esophagitis in Canton of Vaud, Switzerland, 1993-2013: a population-based study.

Details

Serval ID
serval:BIB_E52EA93C277F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Escalating incidence of eosinophilic esophagitis in Canton of Vaud, Switzerland, 1993-2013: a population-based study.
Journal
Allergy
Author(s)
Giriens B., Yan P., Safroneeva E., Zwahlen M., Reinhard A., Nydegger A., Vavricka S., Sempoux C., Straumann A., Schoepfer A.M.
ISSN
1398-9995 (Electronic)
ISSN-L
0105-4538
Publication state
Published
Issued date
12/2015
Peer-reviewed
Oui
Volume
70
Number
12
Pages
1633-1639
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication types: Journal Article ; Research Support, Non-U.S. Gov't

Abstract
Eosinophilic esophagitis (EoE) is a chronic, inflammatory disease of the esophagus with a rapidly increasing incidence. However, population-based epidemiologic data on EoE are rare and limited to regions with less than 200,000 inhabitants. We evaluated the incidence and prevalence of EoE over time in Canton of Vaud, Switzerland.
Canton of Vaud lies in the French-speaking, Western part of Switzerland. As of December 2013, it had a population of 743,317 inhabitants. We contacted all pathology institutes (n = 6) in this canton to identify patients that have been diagnosed with esophageal eosinophilia between 1993 and 2013. We then performed a chart review in all adult and pediatric gastroenterology practices to identify patients with EoE.
Of 263 patients with esophageal eosinophilia, a total of 179 fulfilled the diagnostic criteria for EoE. Median diagnostic delay was 4 (IQR 1-9) years. No patient was diagnosed with EoE prior to 2003. Incidence of EoE increased from 0.16/100,000 inhabitants in 2004 to 6.3/100,000 inhabitants in 2013 (P < 0.001). The cumulative EoE prevalence in 2013 was 24.1/100,000. The incidence in males was 2.8 times higher (95% CI 2.01-3.88, P < 0.001) when compared to that in females. The annual EoE incidence was 10.6 times higher (95%-CI 7.61-14.87, P < 0.001) in the period from 2010 to 2013 when compared to that in the period from 1993 to 2009.
The incidence and cumulative prevalence of EoE in Canton of Vaud, Switzerland, has rapidly increased in the past 10 years.

Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Eosinophilic Esophagitis/epidemiology, Female, Humans, Incidence, Male, Middle Aged, Prevalence, Switzerland/epidemiology, Young Adult
Pubmed
Web of science
Create date
27/08/2015 9:27
Last modification date
20/08/2019 16:08
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