Effects of particulate matter on inflammatory markers in the general adult population.

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Version: Final published version
License: Not specified
Serval ID
serval:BIB_E523A633CFE2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of particulate matter on inflammatory markers in the general adult population.
Journal
Particle and Fibre Toxicology
Author(s)
Tsai Dai-Hua, Amyai Nadia, Marques-Vidal Pedro, Wang Jia-lin, Riediker Michael, Mooser Vincent, Paccaud Fred, Waeber Gerard, Vollenweider Peter, Bochud Murielle
ISSN
1743-8977 (Electronic)
ISSN-L
1743-8977
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
9
Pages
art. 24 [9 p.]
Language
english
Notes
Publication types: Journal Article
Abstract
BACKGROUND: Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway.¦METHODS: We used baseline data from the CoLaus Study including 6183 adult participants residing in Lausanne, Switzerland. We analyzed the association of short-term exposure to PM10 (on the day of examination visit) with continuous circulating serum levels of high-sensitive C-reactive protein (hs-CRP), interleukin 1-beta (IL-1β), interleukin 6 (IL-6), and tumor-necrosis-factor alpha (TNF-α) by robust linear regressions, controlling for potential confounding factors and assessing effect modification.¦RESULTS: In adjusted analyses, for every 10 μg/m3 elevation in PM10, IL-1ß increased by 0.034 (95 % confidence interval, 0.007-0.060) pg/mL, IL-6 by 0.036 (0.015-0.057) pg/mL, and TNF-α by 0.024 (0.013-0.035) pg/mL, whereas no significant association was found with hs-CRP levels.¦CONCLUSIONS: Short-term exposure to PM10 was positively associated with higher levels of circulating IL-1ß, IL-6 and TNF-α in the adult general population. This positive association suggests a link between air pollution and cardiovascular risk, although further studies are needed to clarify the mechanistic pathway linking PM10 to cardiovascular risk.
Pubmed
Web of science
Open Access
Yes
Create date
13/07/2012 8:57
Last modification date
22/07/2020 5:22
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