New insights into CNS development from multiomics approaches.

Details

Serval ID
serval:BIB_E4F0F807E8B5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
New insights into CNS development from multiomics approaches.
Journal
Current opinion in neurobiology
Author(s)
Solanelles-Farré L., Telley L.
ISSN
1873-6882 (Electronic)
ISSN-L
0959-4388
Publication state
Published
Issued date
07/11/2020
Peer-reviewed
Oui
Volume
66
Pages
116-124
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Our understanding of the central nervous system (CNS) development has been strongly enhanced by the recent progress of single-cell multiomics approaches. Certainly, the multiplex profiling of individual cell epigenomes and transcriptomes together with dynamic lineage tracing systems brings encouraging new perspectives and prompts a paradigm shift in neuroscience developmental research. In this review, we outline the latest multiomics -based findings in CNS development, from the early CNS patterning to the regional specification of the CNS along anterior-posterior axis (forebrain, midbrain, hindbrain and spinal cord). Overall, multiomics development has substantially impacted current knowledge and has challenged our classical models for embryonic CNS development. Integrating all these newly generated -omics databases represents the next step to overcome challenges in understanding developmental diseases.
Pubmed
Open Access
Yes
Create date
16/11/2020 14:29
Last modification date
18/12/2020 6:26
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